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Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets

1
Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
2
College of Animal Science and Technology, Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China
3
Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian 271018, China
*
Author to whom correspondence should be addressed.
Genes 2020, 11(1), 44; https://doi.org/10.3390/genes11010044
Received: 11 November 2019 / Revised: 24 December 2019 / Accepted: 27 December 2019 / Published: 30 December 2019
(This article belongs to the Section Microbial Genetics and Genomics)
Porcine epidemic diarrhea (PED) is a major gastrointestinal disease afflicting suckling pigs that causes huge industrial economic losses. In this study, we investigated microbiota from the colonic mucosa and content in healthy and PED piglets. High-throughput 16S rRNA gene sequencing was performed to identify inter-group differences. Firmicutes, Fusobacteria, Proteobacteria, and Bacteroidetes were the top four affected phyla. The proportion of Proteobacteria was higher in infected than in healthy piglets, and the opposite was observed for Bacteroidetes (more than four-fold higher in the healthy group). In the infected group, Fusobacterium accounted for 36.56% and 21.61% in the colonic mucosa and contents, respectively, while in the healthy group, they comprised 22.53% and 12.67%, respectively. The percentage of Lactobacillus in healthy colons (15.63%) was considerably higher than that in the disease group (<10%). In both the colonic mucosa and contents, functional enrichment differed significantly between healthy and diseased groups. Overall, infection with the PED virus increased the proportion of harmful bacteria and decreased the proportion of beneficial bacteria in the colons of piglets. Targeting intestinal microbiota could be a promising method for PED prevention, thus opening new avenues for future research. View Full-Text
Keywords: colonic microbiota; porcine epidemic diarrhea virus; 16S rRNA gene; colonic mucosa; suckling pigs colonic microbiota; porcine epidemic diarrhea virus; 16S rRNA gene; colonic mucosa; suckling pigs
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MDPI and ACS Style

Tan, Z.; Dong, W.; Ding, Y.; Ding, X.; Zhang, Q.; Jiang, L. Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets. Genes 2020, 11, 44. https://doi.org/10.3390/genes11010044

AMA Style

Tan Z, Dong W, Ding Y, Ding X, Zhang Q, Jiang L. Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets. Genes. 2020; 11(1):44. https://doi.org/10.3390/genes11010044

Chicago/Turabian Style

Tan, Zhen, Wanting Dong, Yaqun Ding, Xiangdong Ding, Qin Zhang, and Li Jiang. 2020. "Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets" Genes 11, no. 1: 44. https://doi.org/10.3390/genes11010044

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