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Review

Biodegradation of Tetralin: Genomics, Gene Function and Regulation

1
Universidad Pablo de Olavide, Departamento de Biología Molecular e Ingeniería Bioquímica, 41013 Seville, Spain
2
Centro Andaluz de Biología del Desarrollo, CSIC, Universidad Pablo de Olavide, Junta de Andalucía, Departamento de Biología Molecular e Ingeniería Bioquímica, 41013 Seville, Spain
*
Author to whom correspondence should be addressed.
Genes 2019, 10(5), 339; https://doi.org/10.3390/genes10050339
Received: 28 March 2019 / Revised: 26 April 2019 / Accepted: 30 April 2019 / Published: 6 May 2019
(This article belongs to the Special Issue Genetics of Biodegradation and Bioremediation)
Tetralin (1,2,3,4-tetrahydonaphthalene) is a recalcitrant compound that consists of an aromatic and an alicyclic ring. It is found in crude oils, produced industrially from naphthalene or anthracene, and widely used as an organic solvent. Its toxicity is due to the alteration of biological membranes by its hydrophobic character and to the formation of toxic hydroperoxides. Two unrelated bacteria, Sphingopyxis granuli strain TFA and Rhodococcus sp. strain TFB were isolated from the same niche as able to grow on tetralin as the sole source of carbon and energy. In this review, we provide an overview of current knowledge on tetralin catabolism at biochemical, genetic and regulatory levels in both strains. Although they share the same biodegradation strategy and enzymatic activities, no evidences of horizontal gene transfer between both bacteria have been found. Moreover, the regulatory elements that control the expression of the gene clusters are completely different in each strain. A special consideration is given to the complex regulation discovered in TFA since three regulatory systems, one of them involving an unprecedented communication between the catabolic pathway and the regulatory elements, act together at transcriptional and posttranscriptional levels to optimize tetralin biodegradation gene expression to the environmental conditions. View Full-Text
Keywords: tetralin; Sphingopyxis granuli strain TFA; Rhodococcus sp. strain TFB; redox proteins; carbon catabolite repression tetralin; Sphingopyxis granuli strain TFA; Rhodococcus sp. strain TFB; redox proteins; carbon catabolite repression
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MDPI and ACS Style

Floriano, B.; Santero, E.; Reyes-Ramírez, F. Biodegradation of Tetralin: Genomics, Gene Function and Regulation. Genes 2019, 10, 339. https://doi.org/10.3390/genes10050339

AMA Style

Floriano B, Santero E, Reyes-Ramírez F. Biodegradation of Tetralin: Genomics, Gene Function and Regulation. Genes. 2019; 10(5):339. https://doi.org/10.3390/genes10050339

Chicago/Turabian Style

Floriano, Belén, Eduardo Santero, and Francisca Reyes-Ramírez. 2019. "Biodegradation of Tetralin: Genomics, Gene Function and Regulation" Genes 10, no. 5: 339. https://doi.org/10.3390/genes10050339

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