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Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting

1
Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland
2
Department of Biochemistry, University of Turku, 20520 Turku, Finland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2020, 9(7), 1624; https://doi.org/10.3390/cells9071624
Received: 1 June 2020 / Revised: 29 June 2020 / Accepted: 1 July 2020 / Published: 6 July 2020
(This article belongs to the Special Issue Actin-Myosin Cytoskeleton Regulation and Function)
Microtubule-associated serine/threonine kinase-like (MASTL; Greatwall) is a well-characterized kinase, whose catalytic role has been extensively studied in relation to cell-cycle acceleration. Importantly, MASTL has been implicated to play a substantial role in cancer progression and subsequent studies have shown that MASTL is a significant regulator of the cellular actomyosin cytoskeleton. Several kinases have non-catalytic properties, which are essential or even sufficient for their functions. Likewise, MASTL functions have been attributed both to kinase-dependent phosphorylation of downstream substrates, but also to kinase-independent regulation of the actomyosin contractile machinery. In this review, we aimed to highlight the catalytic and non-catalytic roles of MASTL in proliferation, migration, and invasion. Further, we discussed the implications of this dual role for therapeutic design. View Full-Text
Keywords: MASTL; actin; contractility; cell cycle; cancer; therapeutic targeting; kinase inhibitor MASTL; actin; contractility; cell cycle; cancer; therapeutic targeting; kinase inhibitor
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MDPI and ACS Style

Conway, J.R.W.; Närvä, E.; Taskinen, M.E.; Ivaska, J. Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting. Cells 2020, 9, 1624.

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