c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis
AbstractCasitas B lineage lymphoma (c-Cbl) is a multifunctional protein with a ubiquitin E3 ligase activity capable of degrading diverse sets of proteins. Although previous work had focused mainly on c-Cbl mutations in humans with hematological malignancies, recent emerging evidence suggests a critical role of c-Cbl in angiogenesis and human solid organ tumors. The combination of its unique structure, modular function, and ability to channelize cues from a rich network of signaling cascades, empowers c-Cbl to assume a central role in these disease models. This review consolidates the structural and functional insights based on recent studies that highlight c-Cbl as a target with tantalizing therapeutic potential in various models of angiogenesis and tumorigenesis. View Full-Text
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Lyle, C.L.; Belghasem, M.; Chitalia, V.C. c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis. Cells 2019, 8, 498.
Lyle CL, Belghasem M, Chitalia VC. c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis. Cells. 2019; 8(5):498.Chicago/Turabian Style
Lyle, Chimera L.; Belghasem, Mostafa; Chitalia, Vipul C. 2019. "c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis." Cells 8, no. 5: 498.
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