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Open AccessReview

c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis

1
Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
2
Department of Pathology and Laboratory Medicine, Boston University Medical Center, Boston, MA 02118, USA
3
Boston Veterans Affairs Healthcare System, Boston, MA 02118, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 498; https://doi.org/10.3390/cells8050498
Received: 7 April 2019 / Revised: 9 May 2019 / Accepted: 10 May 2019 / Published: 23 May 2019
(This article belongs to the Special Issue Angiogenesis in Cancer)
Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with a ubiquitin E3 ligase activity capable of degrading diverse sets of proteins. Although previous work had focused mainly on c-Cbl mutations in humans with hematological malignancies, recent emerging evidence suggests a critical role of c-Cbl in angiogenesis and human solid organ tumors. The combination of its unique structure, modular function, and ability to channelize cues from a rich network of signaling cascades, empowers c-Cbl to assume a central role in these disease models. This review consolidates the structural and functional insights based on recent studies that highlight c-Cbl as a target with tantalizing therapeutic potential in various models of angiogenesis and tumorigenesis. View Full-Text
Keywords: angiogenesis; tumors; ubiquitination; proteasomal degradation; c-Cbl; RTK; non-RTK; VEGFR; FGFR; PDGFR; EGFR; c-Met; Wnt signaling; β–catenin; PLCγ1 angiogenesis; tumors; ubiquitination; proteasomal degradation; c-Cbl; RTK; non-RTK; VEGFR; FGFR; PDGFR; EGFR; c-Met; Wnt signaling; β–catenin; PLCγ1
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MDPI and ACS Style

Lyle, C.L.; Belghasem, M.; Chitalia, V.C. c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis. Cells 2019, 8, 498.

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