Next Article in Journal
Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection
Next Article in Special Issue
Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors
Previous Article in Journal
Intermediate Filaments as Effectors of Cancer Development and Metastasis: A Focus on Keratins, Vimentin, and Nestin
Previous Article in Special Issue
Improved Antitumor Efficacy of Combined Vaccine Based on the Induced HUVECs and DC-CT26 Against Colorectal Carcinoma
Open AccessReview

c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis

1
Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
2
Department of Pathology and Laboratory Medicine, Boston University Medical Center, Boston, MA 02118, USA
3
Boston Veterans Affairs Healthcare System, Boston, MA 02118, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 498; https://doi.org/10.3390/cells8050498
Received: 7 April 2019 / Revised: 9 May 2019 / Accepted: 10 May 2019 / Published: 23 May 2019
(This article belongs to the Special Issue Angiogenesis in Cancer)
  |  
PDF [4634 KB, uploaded 23 May 2019]
  |  

Abstract

Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with a ubiquitin E3 ligase activity capable of degrading diverse sets of proteins. Although previous work had focused mainly on c-Cbl mutations in humans with hematological malignancies, recent emerging evidence suggests a critical role of c-Cbl in angiogenesis and human solid organ tumors. The combination of its unique structure, modular function, and ability to channelize cues from a rich network of signaling cascades, empowers c-Cbl to assume a central role in these disease models. This review consolidates the structural and functional insights based on recent studies that highlight c-Cbl as a target with tantalizing therapeutic potential in various models of angiogenesis and tumorigenesis. View Full-Text
Keywords: angiogenesis; tumors; ubiquitination; proteasomal degradation; c-Cbl; RTK; non-RTK; VEGFR; FGFR; PDGFR; EGFR; c-Met; Wnt signaling; β–catenin; PLCγ1 angiogenesis; tumors; ubiquitination; proteasomal degradation; c-Cbl; RTK; non-RTK; VEGFR; FGFR; PDGFR; EGFR; c-Met; Wnt signaling; β–catenin; PLCγ1
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Lyle, C.L.; Belghasem, M.; Chitalia, V.C. c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis. Cells 2019, 8, 498.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top