Next Article in Journal
The Precision Control of Autophagic Flux and Vesicle Dynamics—A Micropattern Approach
Next Article in Special Issue
Predicting MicroRNA Mediated Gene Regulation between Human and Viruses
Previous Article in Journal
MicroRNAs and Osteoarthritis
Previous Article in Special Issue
Tensor Decomposition-Based Unsupervised Feature Extraction Can Identify the Universal Nature of Sequence-Nonspecific Off-Target Regulation of mRNA Mediated by MicroRNA Transfection
Open AccessReview

The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications

1
Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver V5Z 1L3, BC, Canada
2
Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver V6T 1Z4, BC, Canada
*
Author to whom correspondence should be addressed.
Cells 2018, 7(8), 93; https://doi.org/10.3390/cells7080093
Received: 9 July 2018 / Revised: 27 July 2018 / Accepted: 29 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue Regulatory microRNA)
Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound structures that play key roles in intercellular communication. EVs are potent regulators of tumorigenesis and function largely via the shuttling of cargo molecules (RNA, DNA, protein, etc.) among cancer cells and the cells of the tumor stroma. EV-based crosstalk can promote proliferation, shape the tumor microenvironment, enhance metastasis, and allow tumor cells to evade immune destruction. In many cases these functions have been linked to the presence of specific cargo molecules. Herein we will review various types of EV cargo molecule and their functional impacts in the context of oncology. View Full-Text
Keywords: extracellular vesicles; cancer; therapeutics extracellular vesicles; cancer; therapeutics
Show Figures

Figure 1

MDPI and ACS Style

Jabalee, J.; Towle, R.; Garnis, C. The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications. Cells 2018, 7, 93.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop