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Cells
Volume 14
Issue 12
10.3390/cells14120856
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Review

The Calcium Signalling Profile of the Inner Blood–Retinal Barrier in Diabetic Retinopathy

by
Francesco Moccia
1 and
Silvia Dragoni
2,*
1
Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy
2
School of Applied Sciences, University of Brighton, Moulsecoomb, Brighton BN24GJ, UK
*
Author to whom correspondence should be addressed.
Cells 2025, 14(12), 856; https://doi.org/10.3390/cells14120856
Submission received: 22 April 2025 / Revised: 28 May 2025 / Accepted: 4 June 2025 / Published: 6 June 2025
(This article belongs to the Special Issue Ca2+ Signaling and Calcium-Binding Proteins in Human Disease)
Versions Notes

Abstract

Diabetic retinopathy is a sight-threatening complication of diabetes mellitus, affecting millions of people worldwide. From a vascular perspective, diabetic retinopathy compromises the structure and function of the blood–retinal barrier, leading to aberrant angiogenesis and vascular leakage, with consequent loss of vision. This review will delve into the vascular abnormalities caused by diabetic retinopathy in the inner blood–retinal barrier, focusing primarily on retinal endothelial cells. It will then discuss how calcium signalling regulates inner blood–retina barrier function and dysfunction, how calcium channels contribute to the development of diabetic retinopathy, and how studying the components of the calcium toolkit may identify new therapeutic targets.
Keywords: diabetic retinopathy; blood–retinal barrier; endothelial dysfunction; calcium signalling diabetic retinopathy; blood–retinal barrier; endothelial dysfunction; calcium signalling

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MDPI and ACS Style

Moccia, F.; Dragoni, S. The Calcium Signalling Profile of the Inner Blood–Retinal Barrier in Diabetic Retinopathy. Cells 2025, 14, 856. https://doi.org/10.3390/cells14120856

AMA Style

Moccia F, Dragoni S. The Calcium Signalling Profile of the Inner Blood–Retinal Barrier in Diabetic Retinopathy. Cells. 2025; 14(12):856. https://doi.org/10.3390/cells14120856

Chicago/Turabian Style

Moccia, Francesco, and Silvia Dragoni. 2025. "The Calcium Signalling Profile of the Inner Blood–Retinal Barrier in Diabetic Retinopathy" Cells 14, no. 12: 856. https://doi.org/10.3390/cells14120856

APA Style

Moccia, F., & Dragoni, S. (2025). The Calcium Signalling Profile of the Inner Blood–Retinal Barrier in Diabetic Retinopathy. Cells, 14(12), 856. https://doi.org/10.3390/cells14120856

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