Gestational CBD Shapes Insular Cortex in Adulthood
Abstract
1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Slice Preparation
2.3. Electrophysiology
2.4. Data Analysis and Statistics
2.5. Statistical Output for Main Figures
3. Results
3.1. Gestational CBD-Induced Sex- and Territory-Specific Alterations in the Properties of IC Pyramidal Neurons
3.2. Gestational Exposure to CBD Altered the Excitability of Pyramidal Neurons in Specific Subregions of the IC
3.3. Territory-Specific Changes in Electrophysiological Correlations Due to Gestational CBD Exposure: Insights from Multivariate Analysis
3.4. Prenatal Cannabidiol Treatment Equalized Excitatory and Inhibitory Synaptic Transmission of the Adult Offspring in a Sex- and Territory-Specific Manner
3.5. Prenatal Cannabidiol Exposure Altered the IC’s Excitatory–Inhibitory Balance IC in a Sex- and Territory-Specific Manner
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Iezzi, D.; Cáceres-Rodríguez, A.; Pereira-Silva, J.; Chavis, P.; Manzoni, O.J.J. Gestational CBD Shapes Insular Cortex in Adulthood. Cells 2024, 13, 1486. https://doi.org/10.3390/cells13171486
Iezzi D, Cáceres-Rodríguez A, Pereira-Silva J, Chavis P, Manzoni OJJ. Gestational CBD Shapes Insular Cortex in Adulthood. Cells. 2024; 13(17):1486. https://doi.org/10.3390/cells13171486
Chicago/Turabian StyleIezzi, Daniela, Alba Cáceres-Rodríguez, Jessica Pereira-Silva, Pascale Chavis, and Olivier Jacques José Manzoni. 2024. "Gestational CBD Shapes Insular Cortex in Adulthood" Cells 13, no. 17: 1486. https://doi.org/10.3390/cells13171486
APA StyleIezzi, D., Cáceres-Rodríguez, A., Pereira-Silva, J., Chavis, P., & Manzoni, O. J. J. (2024). Gestational CBD Shapes Insular Cortex in Adulthood. Cells, 13(17), 1486. https://doi.org/10.3390/cells13171486