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MDPIMDPI
by
  • Stelian Adrian Ritiu1,2,†,
  • Alexandru Florin Rogobete1,2,3,* and
  • Adriana Pistol4
  • et al.

Reviewer 1: Yaswanth Kuthati Reviewer 2: Cyrus Motamed

Round 1

Reviewer 1 Report

REVIEVER’S REPORT:

This review paper summarizes the research related to the impact of molecular and cellular mechanisms involved in inflammation induced by surgery and anesthesia in patients and the use of antioxidative therapies to minimize inflammation and complications post-surgery. The paper is generally well written and merits publication; however, the quality of the paper can be enhanced if the following points can be addressed.

 

1English Language and Style:  There are many grammatical issues which need to be resolved before accepting this manuscript. For example:

There are several run-on sentences in the manuscript, which need to be revised. For example: Line 75-78

There are a few spelling and grammar mistakes which need to be checked, for example: Line 60 “immuno-inflammatory”, Line 106 - Exogenous

 

Other comments:

1  I suggest the authors to tabulate the analgesics used and their impact on inflammatory parameters. Similarly, it would be better if the authors can tabulate the list of antioxidants and their beneficial effects on surgery and recovery. This would make it easy for the readers to understand the advantages or limitations with each analgesic.

Reviewer 2 Report

Thank you for permitting me to review this manuscript 

Introduction 

at the end of the introduction , the primary objective of the review should be cited , the three last sentences are unnecessary  and may be relocated in the discussion section 

conclusions 

lower opioid  requirement after antioxydant therapy is dubious for me especially with the antioxydant displayed in this review 

Redox disturbances should be defined before it appears in a sub chapter 

 

figure 1 legnd 

the pink rectangle need more explanation 

such as ROS,?

Line 234 : transition from general anesthesia ventilation to RS is not clear 

please  provide reference 

the OS in cardiac surgery , lung transplant and one lung ventilation is obviously not the same as a simple patient ventilation for other current surgeries not related to lungs as part of standard general anesthesia practice 

Line 346 the immunosuppressive effects of morphine are mostly cited in laboratory  findings not really in clinical practice  as stated by authors themselves later in the same paragraph  ,  therefore theses general  statements  without real clinical foundations should be avoided or at least 

Line 350 PPR