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Article

Beneficial Effects of Resveratrol in Mouse Gastrocnemius: A Hint to Muscle Phenotype and Proteolysis

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Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, Pulmonology Department, IMIM—Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain
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Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona Biomedical Research Park (PRBB), 08003 Barcelona, Spain
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Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 08003 Barcelona, Spain
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Department of Pharmacy, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain
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Scientific and Technical Department, Hospital del Mar-IMIM, 08003 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Sabah Hussain and Kunihiro Sakuma
Cells 2021, 10(9), 2436; https://doi.org/10.3390/cells10092436
Received: 16 July 2021 / Revised: 8 September 2021 / Accepted: 13 September 2021 / Published: 15 September 2021
We hypothesized that the phenolic compound resveratrol mitigates muscle protein degradation and loss and improves muscle fiber cross-sectional area (CSA) in gastrocnemius of mice exposed to unloading (7dI). In gastrocnemius of mice (female C57BL/6J, 10 weeks) exposed to a seven-day period of hindlimb immobilization with/without resveratrol treatment, markers of muscle proteolysis (tyrosine release, systemic troponin-I), atrophy signaling pathways, and muscle phenotypic features and function were analyzed. In gastrocnemius of unloaded mice treated with resveratrol, body and muscle weight and function were attenuated, whereas muscle proteolysis (tyrosine release), proteolytic and apoptotic markers, atrophy signaling pathways, and myofiber CSA significantly improved. Resveratrol treatment of mice exposed to a seven-day period of unloading prevented body and muscle weight and limb strength loss, while an improvement in muscle proteolysis, proteolytic markers, atrophy signaling pathways, apoptosis, and muscle fiber CSA was observed in the gastrocnemius muscle. These findings may have potential therapeutic implications in the management of disuse muscle atrophy in clinical settings. View Full-Text
Keywords: disuse muscle atrophy; chronic conditions; limb muscles; resveratrol; proteolysis; apoptosis; muscle fiber cross-sectional areas; atrophy signaling pathways disuse muscle atrophy; chronic conditions; limb muscles; resveratrol; proteolysis; apoptosis; muscle fiber cross-sectional areas; atrophy signaling pathways
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MDPI and ACS Style

Mañas-García, L.; Denhard, C.; Mateu, J.; Duran, X.; Gea, J.; Barreiro, E. Beneficial Effects of Resveratrol in Mouse Gastrocnemius: A Hint to Muscle Phenotype and Proteolysis. Cells 2021, 10, 2436. https://doi.org/10.3390/cells10092436

AMA Style

Mañas-García L, Denhard C, Mateu J, Duran X, Gea J, Barreiro E. Beneficial Effects of Resveratrol in Mouse Gastrocnemius: A Hint to Muscle Phenotype and Proteolysis. Cells. 2021; 10(9):2436. https://doi.org/10.3390/cells10092436

Chicago/Turabian Style

Mañas-García, Laura, Charlotte Denhard, Javier Mateu, Xavier Duran, Joaquim Gea, and Esther Barreiro. 2021. "Beneficial Effects of Resveratrol in Mouse Gastrocnemius: A Hint to Muscle Phenotype and Proteolysis" Cells 10, no. 9: 2436. https://doi.org/10.3390/cells10092436

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