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Review

Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review

1
Department of Biological Sciences, School of Medicine and Life Sciences, Sunway University, Petaling Jaya 47500, Malaysia
2
Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, L4 Laboratory Block, Hong Kong
3
Institute of Ocean and Earth Sciences, Universiti Malaya, Kuala Lumpur 50603, Malaysia
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Faculty of Applied Sciences, UCSI University, Cheras, Kuala Lumpur 56000, Malaysia
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Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia
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Department of Anatomy, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia
*
Authors to whom correspondence should be addressed.
Academic Editor: FengRu Tang
Cells 2021, 10(9), 2194; https://doi.org/10.3390/cells10092194
Received: 24 July 2021 / Revised: 20 August 2021 / Accepted: 20 August 2021 / Published: 25 August 2021
(This article belongs to the Special Issue Induced Impairment of Neurogenesis and Brain Diseases)
Despite the progressive advances, current standards of treatments for peripheral nerve injury do not guarantee complete recovery. Thus, alternative therapeutic interventions should be considered. Complementary and alternative medicines (CAMs) are widely explored for their therapeutic value, but their potential use in peripheral nerve regeneration is underappreciated. The present systematic review, designed according to guidelines of Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols, aims to present and discuss the current literature on the neuroregenerative potential of CAMs, focusing on plants or herbs, mushrooms, decoctions, and their respective natural products. The available literature on CAMs associated with peripheral nerve regeneration published up to 2020 were retrieved from PubMed, Scopus, and Web of Science. According to current literature, the neuroregenerative potential of Achyranthes bidentata, Astragalus membranaceus, Curcuma longa, Panax ginseng, and Hericium erinaceus are the most widely studied. Various CAMs enhanced proliferation and migration of Schwann cells in vitro, primarily through activation of MAPK pathway and FGF-2 signaling, respectively. Animal studies demonstrated the ability of CAMs to promote peripheral nerve regeneration and functional recovery, which are partially associated with modulations of neurotrophic factors, pro-inflammatory cytokines, and anti-apoptotic signaling. This systematic review provides evidence for the potential use of CAMs in the management of peripheral nerve injury. View Full-Text
Keywords: complementary and alternative medicines; natural products; peripheral nerve injury; nerve repair; nerve regeneration; functional recovery complementary and alternative medicines; natural products; peripheral nerve injury; nerve repair; nerve regeneration; functional recovery
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MDPI and ACS Style

Yow, Y.-Y.; Goh, T.-K.; Nyiew, K.-Y.; Lim, L.-W.; Phang, S.-M.; Lim, S.-H.; Ratnayeke, S.; Wong, K.-H. Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review. Cells 2021, 10, 2194. https://doi.org/10.3390/cells10092194

AMA Style

Yow Y-Y, Goh T-K, Nyiew K-Y, Lim L-W, Phang S-M, Lim S-H, Ratnayeke S, Wong K-H. Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review. Cells. 2021; 10(9):2194. https://doi.org/10.3390/cells10092194

Chicago/Turabian Style

Yow, Yoon-Yen, Tiong-Keat Goh, Ke-Ying Nyiew, Lee-Wei Lim, Siew-Moi Phang, Siew-Huah Lim, Shyamala Ratnayeke, and Kah-Hui Wong. 2021. "Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review" Cells 10, no. 9: 2194. https://doi.org/10.3390/cells10092194

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