Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019
Abstract
:1. Introduction
2. Renin-Angiotensin-Aldosterone System
3. Virology of SARS-CoV2
4. ACE2 and Organ Tropism of SARS-CoV2
- The virus may travel by retrograde axonal transport through sensory and olfactory nerves [97]. This pathway could account for COVID-19 related anosmia and ageusia.
- An alternative route is through the dissemination of SARS-CoV-2 into the systemic circulation following infection of the respiratory tract [98].
5. RAAS Dysfunction in COVID-19 Pathogenesis
6. RAAS Targeting Drugs and COVID-19
7. Future Directions
Author Contributions
Funding
Conflicts of Interest
References
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Zanza, C.; Tassi, M.F.; Romenskaya, T.; Piccolella, F.; Abenavoli, L.; Franceschi, F.; Piccioni, A.; Ojetti, V.; Saviano, A.; Canonico, B.; et al. Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019. Cells 2021, 10, 1752. https://doi.org/10.3390/cells10071752
Zanza C, Tassi MF, Romenskaya T, Piccolella F, Abenavoli L, Franceschi F, Piccioni A, Ojetti V, Saviano A, Canonico B, et al. Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019. Cells. 2021; 10(7):1752. https://doi.org/10.3390/cells10071752
Chicago/Turabian StyleZanza, Christian, Michele Fidel Tassi, Tatsiana Romenskaya, Fabio Piccolella, Ludovico Abenavoli, Francesco Franceschi, Andrea Piccioni, Veronica Ojetti, Angela Saviano, Barbara Canonico, and et al. 2021. "Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019" Cells 10, no. 7: 1752. https://doi.org/10.3390/cells10071752