Next Article in Journal
Emerging Roles of Small GTPases in Islet β-Cell Function
Next Article in Special Issue
Role of Extracellular Vesicles in Cell Death and Inflammation
Previous Article in Journal
C-REV Retains High Infectivity Regardless of the Expression Levels of cGAS and STING in Cultured Pancreatic Cancer Cells
Previous Article in Special Issue
Temporal Quantitative Proteomics Analysis of Neuroblastoma Cells Treated with Bovine Milk-Derived Extracellular Vesicles Highlights the Anti-Proliferative Properties of Milk-Derived Extracellular Vesicles
Review

EV Cargo Sorting in Therapeutic Development for Cardiovascular Disease

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, One Gustav L. Levy, P.O. Box 1030, New York, NY 10029, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Michela Pozzobon
Cells 2021, 10(6), 1500; https://doi.org/10.3390/cells10061500
Received: 30 September 2020 / Revised: 24 October 2020 / Accepted: 28 October 2020 / Published: 15 June 2021
(This article belongs to the Special Issue Extracellular Vesicles: Biogenesis, Cargo and Disease)
Cardiovascular disease remains the leading cause of morbidity and mortality in the world. Thus, therapeutic interventions to circumvent this growing burden are of utmost importance. Extracellular vesicles (EVs) actively secreted by most living cells, play a key role in paracrine and endocrine intercellular communication via exchange of biological molecules. As the content of secreted EVs reflect the physiology and pathology of the cell of their origin, EVs play a significant role in cellular homeostasis, disease pathogenesis and diagnostics. Moreover, EVs are gaining popularity in clinics as therapeutic and drug delivery vehicles, transferring bioactive molecules such as proteins, genes, miRNAs and other therapeutic agents to target cells to treat diseases and deter disease progression. Despite our limited but growing knowledge of EV biology, it is imperative to understand the complex mechanisms of EV cargo sorting in pursuit of designing next generation EV-based therapeutic delivery systems. In this review, we highlight the mechanisms of EV cargo sorting and methods of EV bioengineering and discuss engineered EVs as a potential therapeutic delivery system to treat cardiovascular disease. View Full-Text
Keywords: cardiovascular disease; extracellular vesicles; exosomes; therapeutics; diagnostics; cargo sorting pathogenesis cardiovascular disease; extracellular vesicles; exosomes; therapeutics; diagnostics; cargo sorting pathogenesis
Show Figures

Figure 1

MDPI and ACS Style

Sherman, C.D.; Lodha, S.; Sahoo, S. EV Cargo Sorting in Therapeutic Development for Cardiovascular Disease. Cells 2021, 10, 1500. https://doi.org/10.3390/cells10061500

AMA Style

Sherman CD, Lodha S, Sahoo S. EV Cargo Sorting in Therapeutic Development for Cardiovascular Disease. Cells. 2021; 10(6):1500. https://doi.org/10.3390/cells10061500

Chicago/Turabian Style

Sherman, Cherrie D., Shweta Lodha, and Susmita Sahoo. 2021. "EV Cargo Sorting in Therapeutic Development for Cardiovascular Disease" Cells 10, no. 6: 1500. https://doi.org/10.3390/cells10061500

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop