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Open AccessReview

The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions

1
Dipartimento di Scienze Biomediche Avanzate, Università Federico II di Napoli, 80131 Napoli, Italy
2
Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Salerno, 84081 Baronissi, Italy
3
Unità per lo Studio delle Patologie Aortiche, Valvolari e Coronariche, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy
*
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 167; https://doi.org/10.3390/cells10010167
Received: 25 November 2020 / Revised: 11 January 2021 / Accepted: 12 January 2021 / Published: 15 January 2021
Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes. View Full-Text
Keywords: GRK2; insulin resistance; diabetes; hypertension; heart failure GRK2; insulin resistance; diabetes; hypertension; heart failure
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MDPI and ACS Style

Sorriento, D.; Rusciano, M.R.; Visco, V.; Fiordelisi, A.; Cerasuolo, F.A.; Poggio, P.; Ciccarelli, M.; Iaccarino, G. The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions. Cells 2021, 10, 167. https://doi.org/10.3390/cells10010167

AMA Style

Sorriento D, Rusciano MR, Visco V, Fiordelisi A, Cerasuolo FA, Poggio P, Ciccarelli M, Iaccarino G. The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions. Cells. 2021; 10(1):167. https://doi.org/10.3390/cells10010167

Chicago/Turabian Style

Sorriento, Daniela; Rusciano, Maria R.; Visco, Valeria; Fiordelisi, Antonella; Cerasuolo, Federica A.; Poggio, Paolo; Ciccarelli, Michele; Iaccarino, Guido. 2021. "The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions" Cells 10, no. 1: 167. https://doi.org/10.3390/cells10010167

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