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MMP-9 Signaling Pathways That Engage Rho GTPases in Brain Plasticity

Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland
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These authors contributed equally to this work.
Cells 2021, 10(1), 166; https://doi.org/10.3390/cells10010166
Received: 18 December 2020 / Revised: 12 January 2021 / Accepted: 12 January 2021 / Published: 15 January 2021
(This article belongs to the Special Issue Rho family of GTPases in Model Organisms and Systems)
The extracellular matrix (ECM) has been identified as a critical factor affecting synaptic function. It forms a functional scaffold that provides both the structural support and the reservoir of signaling molecules necessary for communication between cellular constituents of the central nervous system (CNS). Among numerous ECM components and modifiers that play a role in the physiological and pathological synaptic plasticity, matrix metalloproteinase 9 (MMP-9) has recently emerged as a key molecule. MMP-9 may contribute to the dynamic remodeling of structural and functional plasticity by cleaving ECM components and cell adhesion molecules. Notably, MMP-9 signaling was shown to be indispensable for long-term memory formation that requires synaptic remodeling. The core regulators of the dynamic reorganization of the actin cytoskeleton and cell adhesion are the Rho family of GTPases. These proteins have been implicated in the control of a wide range of cellular processes occurring in brain physiology and pathology. Here, we discuss the contribution of Rho GTPases to MMP-9-dependent signaling pathways in the brain. We also describe how the regulation of Rho GTPases by post-translational modifications (PTMs) can influence these processes. View Full-Text
Keywords: small Rho GTPases; extracellular matrix; MMP-9; synaptic plasticity; post-translational modifications small Rho GTPases; extracellular matrix; MMP-9; synaptic plasticity; post-translational modifications
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MDPI and ACS Style

Figiel, I.; Kruk, P.K.; Zaręba-Kozioł, M.; Rybak, P.; Bijata, M.; Wlodarczyk, J.; Dzwonek, J. MMP-9 Signaling Pathways That Engage Rho GTPases in Brain Plasticity. Cells 2021, 10, 166. https://doi.org/10.3390/cells10010166

AMA Style

Figiel I, Kruk PK, Zaręba-Kozioł M, Rybak P, Bijata M, Wlodarczyk J, Dzwonek J. MMP-9 Signaling Pathways That Engage Rho GTPases in Brain Plasticity. Cells. 2021; 10(1):166. https://doi.org/10.3390/cells10010166

Chicago/Turabian Style

Figiel, Izabela; Kruk, Patrycja K.; Zaręba-Kozioł, Monika; Rybak, Paulina; Bijata, Monika; Wlodarczyk, Jakub; Dzwonek, Joanna. 2021. "MMP-9 Signaling Pathways That Engage Rho GTPases in Brain Plasticity" Cells 10, no. 1: 166. https://doi.org/10.3390/cells10010166

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