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Polymers 2017, 9(8), 369; https://doi.org/10.3390/polym9080369

Constraining Polymers into β-Turns: Miscibility and Phase Segregation Effects in Lipid Monolayers

1
Faculty of Natural Science II, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 4, 06120 Halle (Saale), Germany
2
School of Physics, University of Exeter, Stocker Road, Exeter EX4, UK
*
Author to whom correspondence should be addressed.
Received: 28 July 2017 / Revised: 11 August 2017 / Accepted: 13 August 2017 / Published: 17 August 2017
(This article belongs to the Special Issue From Amphiphilic to Polyphilic Polymers)
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Abstract

Abstract: Investigation of model biomembranes and their interactions with natural or synthetic macromolecules are of great interest to design membrane systems with specific properties such as drug-delivery. Here we study the behavior of amphiphilic β-turn mimetic polymer conjugates at the air–water interface and their interactions with lipid model membranes. For this endeavor we synthesized two different types of conjugates containing either hydrophobic polyisobutylene (PIB, Mn = 5000 g·mol−1) or helical poly(n-hexyl isocyanate) (PHIC, Mn = 4000 g·mol−1), both polymers being immiscible, whereas polyisobutylene as a hydrophobic polymer can incorporate into lipid membranes. The conjugates were investigated using Langmuir-film techniques coupled with epifluorescence microscopy and AFM (Atomic Force Microscopy), in addition to their phase behavior in mixed lipid/polymer membranes composed of DPPC (dipalmitoyl-sn-glycero-3-phosphocholine). It was found that the DPPC monolayers are strongly disturbed by the presence of the polymer conjugates and that domain formation of the polymer conjugates occurs at high surface pressures (π > 30 mN·m−1). View Full-Text
Keywords: amphiphilic; copolymers; biomembranes; helical polymers; β-turns; lipid model membrane; Langmuir monolayer amphiphilic; copolymers; biomembranes; helical polymers; β-turns; lipid model membrane; Langmuir monolayer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Deike, S.; Malke, M.; Lechner, B.-D.; Binder, W.H. Constraining Polymers into β-Turns: Miscibility and Phase Segregation Effects in Lipid Monolayers. Polymers 2017, 9, 369.

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