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Open AccessFeature PaperArticle

l-Cystine-Crosslinked Polypeptide Nanogel as a Reduction-Responsive Excipient for Prostate Cancer Chemotherapy

by 1,2,†, 2,†, 3,*, 2, 1,2, 1,2, 1,* and 2,*
1
Department of Urology, the First Hospital of Jilin University, Changchun 130021, China
2
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan 250117, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Carsten Werner
Polymers 2016, 8(2), 36; https://doi.org/10.3390/polym8020036
Received: 19 December 2015 / Revised: 21 January 2016 / Accepted: 26 January 2016 / Published: 29 January 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
Smart polymer nanogel-assisted drug delivery systems have attracted more and more attention in cancer chemotherapy because of their well-defined morphologies and pleiotropic functions in recent years. In this work, an l-cystine-crosslinked reduction-responsive polypeptide nanogel of methoxy poly(ethylene glycol)-poly(l-phenylalanine-co-l-cystine) (mPEG-P(LP-co-LC)) was employed as a smart excipient for RM-1 prostate cancer (PCa) chemotherapy. Doxorubicin (DOX), as a regular chemotherapy drug, was embedded in the nanogel. The loading nanogel marked as NG/DOX was shown to exhibit glutathione (GSH)-induced swelling and GSH-accelerated DOX release. Subsequently, NG/DOX showed efficient cellular uptake and proliferation inhibition. Furthermore, NG/DOX presented enhanced antitumor efficacy and security in an RM-1 PCa-grafted mouse model in vivo, indicating its great potential for clinical treatment. View Full-Text
Keywords: chemotherapy; l-cystine; polypeptide nanogel; prostate cancer; reduction-responsiveness; smart drug delivery chemotherapy; l-cystine; polypeptide nanogel; prostate cancer; reduction-responsiveness; smart drug delivery
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MDPI and ACS Style

He, L.; Li, D.; Wang, Z.; Xu, W.; Wang, J.; Guo, H.; Wang, C.; Ding, J. l-Cystine-Crosslinked Polypeptide Nanogel as a Reduction-Responsive Excipient for Prostate Cancer Chemotherapy. Polymers 2016, 8, 36.

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