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Open AccessArticle

Calcite Biohybrids as Microenvironment for Stem Cells

Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Author to whom correspondence should be addressed.
Polymers 2012, 4(2), 1065-1083;
Received: 20 February 2012 / Revised: 11 April 2012 / Accepted: 12 April 2012 / Published: 23 April 2012
A new type of composite 3D biomaterial that provides extracellular cues that govern the differentiation processes of mesenchymal stem cells (MSCs) has been developed. In the present study, we evaluated the chondrogenecity of a biohybrid composed of a calcium carbonate scaffold in its calcite polymorph and hyaluronic acid (HA). The source of the calcite scaffolding is an exoskeleton of a sea barnacle Tetraclita rifotincta (T. rifotincta), Pilsbry (1916). The combination of a calcium carbonate-based bioactive scaffold with a natural polymeric hydrogel is designed to mimic the organic-mineral composite of developing bone by providing a fine-tuned microenvironment. The results indicate that the calcite-HA interface creates a suitable microenvironment for the chondrogenic differentiation of MSCs, and therefore, the biohybrid may provide a tool for tissue-engineered cartilage. View Full-Text
Keywords: calcium carbonate; mesenchymal stem cells (MSCs); chondrogenesity; hyaluronic acid (HA) calcium carbonate; mesenchymal stem cells (MSCs); chondrogenesity; hyaluronic acid (HA)
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Astachov, L.; Nevo, Z.; Vago, R. Calcite Biohybrids as Microenvironment for Stem Cells. Polymers 2012, 4, 1065-1083.

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