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Communication

Localized Enzyme-Assisted Self-Assembly in the Presence of Hyaluronic Acid for Hybrid Supramolecular Hydrogel Coating

1
Institut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France
2
Institut National de la Santé et de la Recherche Médicale, INSERM Unité 1121, CRBS, 1 rue Eugène Boeckel, CEDEX, 67085 Strasbourg, France
3
Faculté de Chirurgie Dentaire, Université de Strasbourg, 8 rue Sainte Elisabeth, 67000 Strasbourg, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Luminita Marin
Polymers 2021, 13(11), 1793; https://doi.org/10.3390/polym13111793
Received: 14 May 2021 / Accepted: 25 May 2021 / Published: 29 May 2021
Hydrogel coating is highly suitable in biomaterial design. It provides biocompatibility and avoids protein adsorption leading to inflammation and rejection of implants. Moreover, hydrogels can be loaded with biologically active compounds. In this field, hyaluronic acid has been largely studied as an additional component since this polysaccharide is naturally present in extracellular matrix. Strategies to direct hydrogelation processes exclusively from the surface using a fully biocompatible approach are rare. Herein we have applied the concept of localized enzyme-assisted self-assembly to direct supramolecular hydrogels in the presence of HA. Based on electronic and fluorescent confocal microscopy, rheological measurements and cell culture investigations, this work highlights the following aspects: (i) the possibility to control the thickness of peptide-based hydrogels at the micrometer scale (18–41 µm) through the proportion of HA (2, 5 or 10 mg/mL); (ii) the structure of the self-assembled peptide nanofibrous network is affected by the growing amount of HA which induces the collapse of nanofibers leading to large assembled microstructures underpinning the supramolecular hydrogel matrix; (iii) this changing internal architecture induces a decrease of the elastic modulus from 2 to 0.2 kPa when concentration of HA is increasing; (iv) concomitantly, the presence of HA in supramolecular hydrogel coatings is suitable for cell viability and adhesion of NIH 3T3 fibroblasts. View Full-Text
Keywords: supramolecular hydrogel; enzyme-assisted self-assembly; hyaluronic acid; peptide; coating supramolecular hydrogel; enzyme-assisted self-assembly; hyaluronic acid; peptide; coating
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MDPI and ACS Style

Rodon Fores, J.; Bigo-Simon, A.; Wagner, D.; Payrastre, M.; Damestoy, C.; Blandin, L.; Boulmedais, F.; Kelber, J.; Schmutz, M.; Rabineau, M.; Criado-Gonzalez, M.; Schaaf, P.; Jierry, L. Localized Enzyme-Assisted Self-Assembly in the Presence of Hyaluronic Acid for Hybrid Supramolecular Hydrogel Coating. Polymers 2021, 13, 1793. https://doi.org/10.3390/polym13111793

AMA Style

Rodon Fores J, Bigo-Simon A, Wagner D, Payrastre M, Damestoy C, Blandin L, Boulmedais F, Kelber J, Schmutz M, Rabineau M, Criado-Gonzalez M, Schaaf P, Jierry L. Localized Enzyme-Assisted Self-Assembly in the Presence of Hyaluronic Acid for Hybrid Supramolecular Hydrogel Coating. Polymers. 2021; 13(11):1793. https://doi.org/10.3390/polym13111793

Chicago/Turabian Style

Rodon Fores, Jennifer, Alexis Bigo-Simon, Déborah Wagner, Mathilde Payrastre, Camille Damestoy, Lucille Blandin, Fouzia Boulmedais, Julien Kelber, Marc Schmutz, Morgane Rabineau, Miryam Criado-Gonzalez, Pierre Schaaf, and Loïc Jierry. 2021. "Localized Enzyme-Assisted Self-Assembly in the Presence of Hyaluronic Acid for Hybrid Supramolecular Hydrogel Coating" Polymers 13, no. 11: 1793. https://doi.org/10.3390/polym13111793

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