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Disordered Mechanical Stress and Tissue Engineering Therapies in Intervertebral Disc Degeneration

Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China
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Polymers 2019, 11(7), 1151; https://doi.org/10.3390/polym11071151
Received: 31 March 2019 / Revised: 27 June 2019 / Accepted: 1 July 2019 / Published: 5 July 2019
(This article belongs to the Special Issue Polymeric Materials for Tissue Engineering)
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Abstract

Low back pain (LBP), commonly induced by intervertebral disc degeneration, is a lumbar disease with worldwide prevalence. However, the mechanism of degeneration remains unclear. The intervertebral disc is a nonvascular organ consisting of three components: Nucleus pulposus, annulus fibrosus, and endplate cartilages. The disc is structured to support our body motion and endure persistent external mechanical pressure. Thus, there is a close connection between force and intervertebral discs in LBP. It is well established that with aging, disordered mechanical stress profoundly influences the fate of nucleus pulposus and the alignment of collagen fibers in the annulus fibrosus. These support a new understanding that disordered mechanical stress plays an important role in the degeneration of the intervertebral discs. Tissue-engineered regenerative and reparative therapies are being developed for relieving disc degeneration and symptoms of lower back pain. In this paper, we will review the current literature available on the role of disordered mechanical stress in intervertebral disc degeneration, and evaluate the existing tissue engineering treatment strategies of the current therapies. View Full-Text
Keywords: disordered mechanical stress; intervertebral disc degeneration; tissue engineering strategies; nucleus pulposus; annulus fibrosus; limitations of therapy disordered mechanical stress; intervertebral disc degeneration; tissue engineering strategies; nucleus pulposus; annulus fibrosus; limitations of therapy
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Zhao, R.; Liu, W.; Xia, T.; Yang, L. Disordered Mechanical Stress and Tissue Engineering Therapies in Intervertebral Disc Degeneration. Polymers 2019, 11, 1151.

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