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Open AccessArticle

Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure

Department of Chemistry and Biochemistry, SBCS, Queen Mary University of London, Mile End Road, London E1 4NS, UK
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Polymers 2019, 11(2), 353; https://doi.org/10.3390/polym11020353
Received: 15 January 2019 / Revised: 12 February 2019 / Accepted: 13 February 2019 / Published: 18 February 2019
Covalently crosslinked nanogels are widely explored as drug delivery systems and sensors. Radical polymerization provides a simple, inexpensive, and broadly applicable approach for their preparation, although the random nature of the reaction requires careful study of the final chemical composition. We demonstrate how the different reactivities of the monomers influence the total degree of incorporation into the polymer matrix and the role played by the experimental parameters in maximizing polymerization efficiency. Nanogels based on N-isopropylacrylamide, N-n-propylacrylamide, and acrylamide crosslinked with N,N’-methylenebisacrylamide were included in this study, in combination with functional monomers N-acryloyl-l-proline, 2-acrylamido-2-methyl-1-propanesulfonic acid, and 4-vinyl-1H-imidazole. Total monomer concentration and initiator quantities are determining parameters for maximizing monomer conversions and chemical yields. The results show that the introduction of functional monomers, changes in the chemical structure of the polymerizable unit, and the addition of templating molecules can all have an effect on the polymerization kinetics. This can significantly impact the final composition of the matrices and their chemical structure, which in turn influence the morphology and properties of the nanogels. View Full-Text
Keywords: nanogels; high dilution radical polymerization; polymeric nanoparticles; monomer conversion; hydrogels; NMR study nanogels; high dilution radical polymerization; polymeric nanoparticles; monomer conversion; hydrogels; NMR study
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MDPI and ACS Style

Liu, P.; Pearce, C.M.; Anastasiadi, R.-M.; Resmini, M.; Castilla, A.M. Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure. Polymers 2019, 11, 353.

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