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Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update

1
School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK
2
School of Life and Medical Sciences, University of Hertfordshire, College Lane, Hatfield AL10 9AB, UK
3
School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(10), 1561; https://doi.org/10.3390/polym11101561
Received: 29 July 2019 / Revised: 9 September 2019 / Accepted: 20 September 2019 / Published: 25 September 2019
(This article belongs to the Special Issue Enzymatic Synthesis of Polymers)
The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile “polymeric-tool” in the broad field of drug delivery. The step-growth polymerization pathway catalyzed by lipase generates a highly functionalizable platform while avoiding tedious steps of protection and deprotection. Synthesis requires only minor purification steps and uses cheap and readily available reagents. The final polymeric material is biodegradable, biocompatible and intrinsically amphiphilic, with a good propensity to self-assemble into nanoparticles (NPs). The free hydroxyl group lends itself to a variety of chemical derivatizations via simple reaction pathways which alter its physico-chemical properties with a possibility to generate an endless number of possible active macromolecules. The present work aims to summarize the available literature about PGA synthesis, architecture alterations, chemical modifications and its application in drug and gene delivery as a versatile carrier. Following on from this, the evolution of the concept of enzymatically-degradable PGA-drug conjugation has been explored, reporting recent examples in the literature. View Full-Text
Keywords: poly(glycerol adipate); lipase; biodegradable; polymeric platforms; functionalization poly(glycerol adipate); lipase; biodegradable; polymeric platforms; functionalization
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MDPI and ACS Style

Swainson, S.M.E.; Styliari, I.D.; Taresco, V.; Garnett, M.C. Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update. Polymers 2019, 11, 1561. https://doi.org/10.3390/polym11101561

AMA Style

Swainson SME, Styliari ID, Taresco V, Garnett MC. Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update. Polymers. 2019; 11(10):1561. https://doi.org/10.3390/polym11101561

Chicago/Turabian Style

Swainson, Sadie M.E., Ioanna D. Styliari, Vincenzo Taresco, and Martin C. Garnett 2019. "Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update" Polymers 11, no. 10: 1561. https://doi.org/10.3390/polym11101561

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