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Open AccessArticle

Synthesis and Properties of Silk Fibroin/Konjac Glucomannan Blend Beads

1
Faculdade de Engenharia Química, Universidade Estadual de Campinas, Campinas 13083-852, São Paulo, Brazil
2
Departamento de Ciencias Matemáticas y Físicas, Facultad de Ingeniería, Universidad Católica de Temuco, Temuco 4813302, Chile
3
Núcleo de Investigación en Bioproductos y Materiales Avanzados (BioMa), Facultad de Ingeniería, Universidad Católica de Temuco, Temuco 4781312, Chile
4
Laboratório de Biotecnologia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas 13083-862, São Paulo, Brazil
*
Author to whom correspondence should be addressed.
Polymers 2018, 10(8), 923; https://doi.org/10.3390/polym10080923
Received: 4 June 2018 / Revised: 25 June 2018 / Accepted: 7 August 2018 / Published: 18 August 2018
(This article belongs to the Special Issue Biocompatible Polymers)
Silk fibroin (SF) and konjac glucomannan (KGM) are promising materials in the biomedical field due to their low toxicity, biocompatibility, biodegradability and low immune response. Beads of these natural polymers are interesting scaffolds for biomedical applications, but their fabrication is a challenge due to their low stability and the necessary adaptation of their chemical and mechanical properties to be successfully applied. In that sense, this study aimed to synthesize a blend of silk fibroin and konjac glucomannan (SF/KGM) in the form of porous beads obtained through dripping into liquid nitrogen, with a post-treatment using ethanol. Intermolecular hydrogen bonds promoted the integration of SF and KGM. Treated beads showed higher porous size, crystallinity, and stability than untreated beads. Characterization analyses by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric (TGA), and X-ray diffraction (XDR) evidenced that ethanol treatment allows a conformational transition from silk I to silk II in SF and an increase in the KGM deacetylation. Those chemical changes significantly enhanced the mechanical resistance of SF/KGM beads in comparison to pure SF and KGM beads. Moreover, samples showed cytocompatibility with HaCaT and BALB/c 3T3 cells. View Full-Text
Keywords: biopolymers; silk fibroin; konjac glucomannan; porous beads; scaffolds; tissue engineering biopolymers; silk fibroin; konjac glucomannan; porous beads; scaffolds; tissue engineering
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França, C.G.; Nascimento, V.F.; Hernandez-Montelongo, J.; Machado, D.; Lancellotti, M.; Beppu, M.M. Synthesis and Properties of Silk Fibroin/Konjac Glucomannan Blend Beads. Polymers 2018, 10, 923.

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