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Polymers 2018, 10(6), 579; https://doi.org/10.3390/polym10060579

Novel PEG-Modified Hybrid PLGA-Vegetable Oils Nanostructured Carriers for Improving Performances of Indomethacin Delivery

1
Advanced Polymer Materials Group, University Politehnica of Bucharest, 1-7 Gh Polizu Street, 011061 Bucharest, Romania
2
Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 1-5 Gh. Polizu Street, 011061 Bucharest, Romania
3
Department of Oxide Materials Science and Engineering, University Politehnica of Bucharest, 1-7 Gh. Polizu, 060042 Bucharest, Romania
4
Academy of Romanian Scientists, 54 Splaiul Independentei Street, 050094 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Received: 26 April 2018 / Revised: 16 May 2018 / Accepted: 22 May 2018 / Published: 24 May 2018
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Abstract

The purpose of this work was to more exhaustively study the influence of nanocarrier matrix composition and also the polyethylene glycol (PEG)-modified surface on the performances of formulations as lipophilic drug delivery systems. Poly (d,l-lactide-co-glycolide), two vegetable oils (Nigella sativa oil and Echium oil) and indomethacin were employed to prepare novel PEG-coated nanocarriers through emulsion solvent evaporation method. The surface modification was achieved by physical PEG adsorption (in the post-production step). Transmission electron microscopy (TEM) nanographs highlighted the core-shell structure of hybrid formulations while scanning electron microscopy (SEM) images showed no obvious morphological changes after PEG adsorption. Drug loading (DL) and entrapment efficiency (EE) varied from 4.6% to 16.4% and 28.7% to 61.4%, solely depending on the type of polymeric matrix. The oil dispersion within hybrid matrix determined a more amorphous structure, as was emphasized by differential scanning calorimetry (DSC) investigations. The release studies highlighted the oil effect upon the ability of nanocarrier to discharge in a more sustained manner the encapsulated drug. Among the kinetic models employed, the Weibull and Korsmeyer-Peppas models showed the better fit (R2 = 0.999 and 0.981) with n < 0.43 indicating a Fickian type release pattern. According to cytotoxic assessment the PEG presence on the surface increased the cellular viability with ~1.5 times as compared to uncoated formulations. View Full-Text
Keywords: hybrid nanocarriers; vegetable oils; indomethacin; PEG surface modification; in vitro release kinetics hybrid nanocarriers; vegetable oils; indomethacin; PEG surface modification; in vitro release kinetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ghitman, J.; Stan, R.; Ghebaur, A.; Cecoltan, S.; Vasile, E.; Iovu, H. Novel PEG-Modified Hybrid PLGA-Vegetable Oils Nanostructured Carriers for Improving Performances of Indomethacin Delivery. Polymers 2018, 10, 579.

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