Next Article in Journal
Effect of Type I Antifreeze Proteins on the Freezing and Melting Processes of Cryoprotective Solutions Studied by Site-Directed Spin Labeling Technique
Previous Article in Journal
Hydrogenation of HOPG-supported Gold Nanoparticles: Features of Initial Stages
Previous Article in Special Issue
Crystal Structure Optimization and Gibbs Free Energy Comparison of Five Sulfathiazole Polymorphs by the Embedded Fragment QM Method at the DFT Level
Article Menu

Export Article

Open AccessArticle

Polymorph Selection of ROY by Flow-Driven Crystallization

1
Nonlinear Physical Chemistry Unit, Université libre de Bruxelles (ULB), 1050 Brussels, Belgium
2
µFlow Group, Department of Chemical Engineering, Vrije Universiteit Brussel, 1050 Brussels, Belgium
3
Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium
*
Authors to whom correspondence should be addressed.
Crystals 2019, 9(7), 351; https://doi.org/10.3390/cryst9070351
Received: 13 May 2019 / Revised: 25 June 2019 / Accepted: 4 July 2019 / Published: 9 July 2019
(This article belongs to the Special Issue Polymorphism in Crystals)
  |  
PDF [8671 KB, uploaded 11 July 2019]
  |  

Abstract

The selection of polymorphs of the organic compound 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile, ROY, is studied experimentally in the confined space between two horizontal glass plates when an acetone solution of ROY of variable concentration is injected at a variable flow rate into water. Depending on the local concentration within the radial flow, a polymorph selection is observed such that red prisms are favored close to the injection center while yellow needles are the preferred polymorph close to the edge of the injected ROY domain. At larger flow rates, a buoyancy-driven instability induces stripes at the outer edge of the displacement pattern, in which specific polymorphs are seen to crystallize. Our results evidence the possibility of a selection of ROY polymorph structures in out-of-equilibrium flow conditions. View Full-Text
Keywords: polymorphism; polymorph selection; ROY; flow-driven crystallization; pattern-formation; buoyancy-driven convection; out-of-equilibrium; Hele-Shaw cell polymorphism; polymorph selection; ROY; flow-driven crystallization; pattern-formation; buoyancy-driven convection; out-of-equilibrium; Hele-Shaw cell
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Ziemecka, I.; Gokalp, S.; Stroobants, S.; Brau, F.; Maes, D.; De Wit, A. Polymorph Selection of ROY by Flow-Driven Crystallization. Crystals 2019, 9, 351.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Crystals EISSN 2073-4352 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top