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Open AccessArticle

Systematic Investigations on Continuous Fluidized Bed Crystallization for Chiral Separation

1
Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstraße 1, 39106 Magdeburg, Germany
2
Sulzer Chemtech Ltd., Gewerbestraße 28, 4123 Allschwil, Switzerland
3
Otto von Guericke University Magdeburg, Institute of Process Engineering, 39106 Magdeburg, Germany
*
Author to whom correspondence should be addressed.
Crystals 2020, 10(5), 394; https://doi.org/10.3390/cryst10050394
Received: 27 April 2020 / Revised: 8 May 2020 / Accepted: 11 May 2020 / Published: 14 May 2020
(This article belongs to the Special Issue Advances in Industrial Crystallization)
A recently developed continuous enantioseparation process utilizing two coupled fluidized bed crystallizers is systematically investigated to identify essential correlations between different operation parameters and the corresponding process performance on the example of asparagine monohydrate. Based on liquid phase composition and product crystal size distribution data, it is proven that steady state operation is achieved reproducibly in a relatively short time. The process outputs at steady state are compared for different feed flow rates, supersaturations, and crystallization temperatures. It is shown that purities >97% are achieved with productivities up to 40 g/L/h. The size distribution, which depends almost exclusively on the liquid flow rate, can be easily adjusted between 260 and 330 µm (mean size) with an almost constant standard deviation of ±55 µm.
Keywords: fluidized bed; continuous; preferential crystallization; chiral separation; racemate resolution; enantiomer; asparagine monohydrate fluidized bed; continuous; preferential crystallization; chiral separation; racemate resolution; enantiomer; asparagine monohydrate
MDPI and ACS Style

Temmel, E.; Gänsch, J.; Seidel-Morgenstern, A.; Lorenz, H. Systematic Investigations on Continuous Fluidized Bed Crystallization for Chiral Separation. Crystals 2020, 10, 394.

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