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Membrane Technology in Catalytic Carbonylation Reactions
Open AccessArticle

Asymmetric Michael Addition of Malononitrile with Chalcones via Rosin-Derived Bifunctional Squaramide

College of Pharmacy, Guangxi Zhuang Yao Medicine Center of Engineering and Technology, Guangxi University of Chinese Medicine, Nanning 530200, China
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Catalysts 2020, 10(1), 14; https://doi.org/10.3390/catal10010014
Received: 4 December 2019 / Revised: 17 December 2019 / Accepted: 19 December 2019 / Published: 20 December 2019
(This article belongs to the Special Issue Catalytic Carbonylation Reactions)
A rosin-derived bifunctional squaramide catalyzed asymmetric Michael addition of malononitrile with chalcones was discovered. This protocol provides a methodology for the facile synthesis of chiral γ-cyano carbonyl compounds in high yields and enantioselectivities (up to 99% yield and 90% ee) with a lower catalyst loading (0.3 mol%). The predominant R-configured adducts were obtained by this organocatalystic reaction, according to the experimental findings. View Full-Text
Keywords: asymmetric catalysis; michael addition; malononitrile; chalcone; rosin-derived bifunctional catalyst asymmetric catalysis; michael addition; malononitrile; chalcone; rosin-derived bifunctional catalyst
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MDPI and ACS Style

Lin, N.; Wei, Q.-X.; Jiang, L.-H.; Deng, Y.-Q.; Zhang, Z.-W.; Chen, Q. Asymmetric Michael Addition of Malononitrile with Chalcones via Rosin-Derived Bifunctional Squaramide. Catalysts 2020, 10, 14. https://doi.org/10.3390/catal10010014

AMA Style

Lin N, Wei Q-X, Jiang L-H, Deng Y-Q, Zhang Z-W, Chen Q. Asymmetric Michael Addition of Malononitrile with Chalcones via Rosin-Derived Bifunctional Squaramide. Catalysts. 2020; 10(1):14. https://doi.org/10.3390/catal10010014

Chicago/Turabian Style

Lin, Ning; Wei, Qiu-Xiang; Jiang, Li-Hua; Deng, Yan-Qiu; Zhang, Zhen-Wei; Chen, Qing. 2020. "Asymmetric Michael Addition of Malononitrile with Chalcones via Rosin-Derived Bifunctional Squaramide" Catalysts 10, no. 1: 14. https://doi.org/10.3390/catal10010014

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