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cMET in NSCLC: Can We Cut off the Head of the Hydra? From the Pathway to the Resistance

Center for Oncological Research Antwerp, University of Antwerp, Universiteitsplein 1, Wilrijk 2610, Belgium
Molecular Pathology Unit, Pathology Department, Antwerp University Hospital, Wilrijkstraat 10, Edegem 2650, Belgium
Department of Oncology, Clínica Universidad de Navarra, Pamplona 31008, Spain
Thoracic Oncology Program, Memorial Cancer Institute, Memorial Health Care System, Pembroke Pines, FL 33024, USA
Medical Oncology Department, Istituto Toscano Tumori, Ospedale Civile, Livorno, Italy viale Alfieri 36, Livorno 57100, Italy
Phase I-Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital, Wilrijkstraat 10, Edegem 2650, Belgium
Author to whom correspondence should be addressed.
Academic Editor: William Cho
Cancers 2015, 7(2), 556-573;
Received: 5 January 2015 / Revised: 19 February 2015 / Accepted: 5 March 2015 / Published: 25 March 2015
(This article belongs to the Special Issue Non-Small Cell Lung Cancer Therapies)
PDF [662 KB, uploaded 25 March 2015]


In the last decade, the tyrosine kinase receptor cMET, together with its ligand hepatocyte growth factor (HGF), has become a target in non-small cell lung cancer (NSCLC). Signalization via cMET stimulates several oncological processes amongst which are cell motility, invasion and metastasis. It also confers resistance against several currently used targeted therapies, e.g., epidermal growth factor receptor (EGFR) inhibitors. In this review, we will discuss the basic structure of cMET and the most important signaling pathways. We will also look into aberrations in the signaling and the effects thereof in cancer growth, with the focus on NSCLC. Finally, we will discuss the role of cMET as resistance mechanism. View Full-Text
Keywords: cMET, NSCLC, targeted therapies cMET, NSCLC, targeted therapies

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Van Der Steen, N.; Pauwels, P.; Gil-Bazo, I.; Castañon, E.; Raez, L.; Cappuzzo, F.; Rolfo, C. cMET in NSCLC: Can We Cut off the Head of the Hydra? From the Pathway to the Resistance. Cancers 2015, 7, 556-573.

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