Next Article in Journal / Special Issue
Epigenetics of Estrogen Receptor Signaling: Role in Hormonal Cancer Progression and Therapy
Previous Article in Journal
Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy
Previous Article in Special Issue
Delineating an Epigenetic Continuum for Initiation, Transformation and Progression to Breast Cancer
Article Menu

Export Article

Open AccessArticle
Cancers 2011, 3(2), 1672-1690;

Role of Gene Methylation in Antitumor Immune Response: Implication for Tumor Progression

Department of Immunology, Hospital Clinico Universitario, Campus Universitario Teatinos S/N, 29010 Malaga, Spain
Department of Biochemistry, CIBER ESP, Hospital Costa del Sol, Marbella, Málaga, Carretera de Cadiz km 187, 29603, Spain
Author to whom correspondence should be addressed.
Received: 22 December 2010 / Revised: 9 March 2011 / Accepted: 24 March 2011 / Published: 29 March 2011
(This article belongs to the Special Issue Epigenetics of Cancer Progression)
Full-Text   |   PDF [188 KB, uploaded 29 March 2011]


Cancer immunosurveillance theory has emphasized the role of escape mechanisms in tumor growth. In this respect, a very important factor is the molecular characterization of the mechanisms by which tumor cells evade immune recognition and destruction. Among the many escape mechanisms identified, alterations in classical and non-classical HLA (Human Leucocyte Antigens) class I and class II expression by tumor cells are of particular interest. In addition to the importance of HLA molecules, tumor-associated antigens and accessory/co-stimulatory molecules are also involved in immune recognition. The loss of HLA class I antigen expression and of co-stimulatory molecules can occur at genetic, transcriptional and post-transcriptional levels. Epigenetic defects are involved in at least some mechanisms that preclude mounting a successful host-antitumor response involving the HLA system, tumor-associated antigens, and accessory/co-stimulatory molecules. This review summarizes our current understanding of the role of methylation in the regulation of molecules involved in the tumor immune response. View Full-Text
Keywords: methylation; tumor; HLA; clusterin methylation; tumor; HLA; clusterin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Serrano, A.; Castro-Vega, I.; Redondo, M. Role of Gene Methylation in Antitumor Immune Response: Implication for Tumor Progression. Cancers 2011, 3, 1672-1690.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top