Magnetic Nanoparticles—A Multifunctional Potential Agent for Diagnosis and Therapy
1
Department of Environmental Sciences, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
2
Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
3
Amity Institute of Biotechnology, Amity University, Noida 201301, India
4
DBT-National Institute of Animal Biotechnology (DBT-NIAB), Hyderabad 500032, India
*
Authors to whom correspondence should be addressed.
Cancers 2021, 13(9), 2213; https://doi.org/10.3390/cancers13092213
Received: 20 April 2021
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Accepted: 1 May 2021
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Published: 5 May 2021
(This article belongs to the Section Methods and Technologies Development)
Simple Summary
Magnetic nanoparticles (MNPs) are highly efficient contrast agents for magnetic resonance imaging for various types of tumors. This review focuses on the various approaches that can be used for selective targeting of MNPs towards a wide variety of solid tumors, with a specific emphasis on the surface modification that can affect the particles distribution in the tissue imparted by different targeting ligands for both in-vitro and in-vivo studies.
Magnetic nanoparticles gained considerable attention in last few years due to their remarkable properties. Superparamaganetism, non-toxicity, biocompatibility, chemical inertness, and environmental friendliness are some of the properties that make iron oxide nanoparticles (IONPs) an ideal choice for biomedical applications. Along with being easily tuneable and a tailored surface for conjugation of IONPs, their physio-chemical and biological properties can also be varied by modifying the basic parameters for synthesis that enhances the additional possibilities for designing novel magnetic nanomaterial for theranostic applications. This review highlights the synthesis, surface modification, and different applications of IONPs for diagnosis, imaging, and therapy. Furthermore, it also represents the recent report on the application of IONPs as enzyme mimetic compounds and a contrasting agent, and its significance in the field as an anticancer and antimicrobial agent.
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Keywords:
iron oxide nanoparticles; cancer; superparamagnetism; tumor microenvironment; magnetic nanoparticles
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MDPI and ACS Style
Chouhan, R.S.; Horvat, M.; Ahmed, J.; Alhokbany, N.; Alshehri, S.M.; Gandhi, S. Magnetic Nanoparticles—A Multifunctional Potential Agent for Diagnosis and Therapy. Cancers 2021, 13, 2213. https://doi.org/10.3390/cancers13092213
AMA Style
Chouhan RS, Horvat M, Ahmed J, Alhokbany N, Alshehri SM, Gandhi S. Magnetic Nanoparticles—A Multifunctional Potential Agent for Diagnosis and Therapy. Cancers. 2021; 13(9):2213. https://doi.org/10.3390/cancers13092213
Chicago/Turabian StyleChouhan, Raghuraj S., Milena Horvat, Jahangeer Ahmed, Norah Alhokbany, Saad M. Alshehri, and Sonu Gandhi. 2021. "Magnetic Nanoparticles—A Multifunctional Potential Agent for Diagnosis and Therapy" Cancers 13, no. 9: 2213. https://doi.org/10.3390/cancers13092213
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