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The Nucleolus and PARP1 in Cancer Biology

Molecular Toxicology Group, Department of Biology, 78457 Konstanz, Germany
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Cancers 2020, 12(7), 1813; https://doi.org/10.3390/cancers12071813
Received: 24 May 2020 / Revised: 26 June 2020 / Accepted: 1 July 2020 / Published: 6 July 2020
(This article belongs to the Special Issue PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer)
The nucleolus has been known for a long time to fulfill crucial functions in ribosome biogenesis, of which cancer cells can become addicted to in order to produce sufficient amounts of proteins for cell proliferation. Recently, the nucleolus has emerged as a central regulatory hub in many other cancer-relevant processes, including stress sensing, DNA damage response, cell cycle control, and proteostasis. This fostered the idea that nucleolar processes can be exploited in cancer therapy. Interestingly, a significant proportion of poly(ADP-ribose) polymerase 1 (PARP1) molecules are localized in the nucleolus and PARP1 also plays crucial roles in many processes that are important in cancer biology, including genome maintenance, replication, transcription, and chromatin remodeling. Furthermore, during the last years, PARP1 came into focus in oncology since it represents a promising target of pharmacological PARP inhibitors in various types of cancers. Here, we provide an overview of our current understanding on the role of PARP1 in nucleolar functions and discuss potential implications in cancer biology and therapy. View Full-Text
Keywords: nucleolus; poly(ADP-ribosyl)ation; PARP; ARTDs; cancer nucleolus; poly(ADP-ribosyl)ation; PARP; ARTDs; cancer
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MDPI and ACS Style

Engbrecht, M.; Mangerich, A. The Nucleolus and PARP1 in Cancer Biology. Cancers 2020, 12, 1813. https://doi.org/10.3390/cancers12071813

AMA Style

Engbrecht M, Mangerich A. The Nucleolus and PARP1 in Cancer Biology. Cancers. 2020; 12(7):1813. https://doi.org/10.3390/cancers12071813

Chicago/Turabian Style

Engbrecht, Marina, and Aswin Mangerich. 2020. "The Nucleolus and PARP1 in Cancer Biology" Cancers 12, no. 7: 1813. https://doi.org/10.3390/cancers12071813

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