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You Have Got a Fast CAR: Chimeric Antigen Receptor NK Cells in Cancer Therapy

Biomedicine Discovery Institute and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
oNKo-Innate Pty Ltd., Clayton, VIC 3800, Australia
Author to whom correspondence should be addressed.
Cancers 2020, 12(3), 706;
Received: 25 January 2020 / Revised: 11 March 2020 / Accepted: 12 March 2020 / Published: 17 March 2020
The clinical success stories of chimeric antigen receptor (CAR)-T cell therapy against B-cell malignancies have contributed to immunotherapy being at the forefront of cancer therapy today. Their success has fueled interest in improving CAR constructs, identifying additional antigens to target, and clinically evaluating them across a wide range of malignancies. However, along with the exciting potential of CAR-T therapy comes the real possibility of serious side effects. While the FDA has approved commercialized CAR-T cell therapy, challenges associated with manufacturing, costs, and related toxicities have resulted in increased attention being paid to implementing CAR technology in innate cytotoxic natural killer (NK) cells. Here, we review the current landscape of the CAR-NK field, from successful clinical implementation to outstanding challenges which remain to be addressed to deliver the full potential of this therapy to more patients. View Full-Text
Keywords: natural killer cells; chimeric antigen receptors; immunotherapy natural killer cells; chimeric antigen receptors; immunotherapy
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Pfefferle, A.; Huntington, N.D. You Have Got a Fast CAR: Chimeric Antigen Receptor NK Cells in Cancer Therapy. Cancers 2020, 12, 706.

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