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SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis

Melanie Swan Memorial Translational Centre, Faculty of Sci-Tech, University of Canberra, Bruce ACT 2617, Australia
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Cancers 2019, 11(8), 1143; https://doi.org/10.3390/cancers11081143
Received: 22 July 2019 / Revised: 5 August 2019 / Accepted: 7 August 2019 / Published: 9 August 2019
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PDF [5358 KB, uploaded 20 August 2019]
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Abstract

The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelial-to-mesenchymal transition and confer resistance to therapies. View Full-Text
Keywords: breast cancer; cancer stem cells; therapy; resistance; recurrence; SETDB1; epigenetics breast cancer; cancer stem cells; therapy; resistance; recurrence; SETDB1; epigenetics
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Batham, J.; Lim, P.S.; Rao, S. SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis. Cancers 2019, 11, 1143.

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