Next Article in Journal
Cancer Metabolism and the Evasion of Apoptotic Cell Death
Next Article in Special Issue
Role of the Microenvironment in Regulating Normal and Cancer Stem Cell Activity: Implications for Breast Cancer Progression and Therapy Response
Previous Article in Journal
Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer
Previous Article in Special Issue
CSCs in Breast Cancer—One Size Does Not Fit All: Therapeutic Advances in Targeting Heterogeneous Epithelial and Mesenchymal CSCs
Open AccessReview

SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis

Melanie Swan Memorial Translational Centre, Faculty of Sci-Tech, University of Canberra, Bruce ACT 2617, Australia
*
Authors to whom correspondence should be addressed.
Cancers 2019, 11(8), 1143; https://doi.org/10.3390/cancers11081143
Received: 22 July 2019 / Revised: 5 August 2019 / Accepted: 7 August 2019 / Published: 9 August 2019
The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing therapies that not only specifically target cancer cells but also the more elusive and aggressive stem cells that contribute to metastasis via epithelial-to-mesenchymal transition and confer resistance to therapies. View Full-Text
Keywords: breast cancer; cancer stem cells; therapy; resistance; recurrence; SETDB1; epigenetics breast cancer; cancer stem cells; therapy; resistance; recurrence; SETDB1; epigenetics
Show Figures

Figure 1

MDPI and ACS Style

Batham, J.; Lim, P.S.; Rao, S. SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis. Cancers 2019, 11, 1143.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop