Circulating Tumour Cell Biomarkers in Head and Neck Cancer: Current Progress and Future Prospects
Abstract
:1. Introduction
2. CTC Biology
3. CTC Isolation Methods
4. CTC Count as a Diagnostic and Prognostic Biomarker in HNSCC
4.1. Diagnostic Biomarker of Stage of Disease
4.2. Prognostic Biomarker of Survival Outcomes and Treatment Response
5. CTC Characterisation in HNSCC
6. Biomarker Led Stratification and Targeted Treatment Guidance
7. Single-Cell Sequencing—The Future of CTC Analysis
7.1. Approaches to CTC Genetic Sequencing
7.2. Single-CTC Genome Sequencing
7.3. Single-CTC Differential Gene-Expression
7.4. Unanswered Questions
8. Conclusions
Funding
Acknowledgments
Conflicts of Interest
References
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Payne, K.; Brooks, J.; Spruce, R.; Batis, N.; Taylor, G.; Nankivell, P.; Mehanna, H. Circulating Tumour Cell Biomarkers in Head and Neck Cancer: Current Progress and Future Prospects. Cancers 2019, 11, 1115. https://doi.org/10.3390/cancers11081115
Payne K, Brooks J, Spruce R, Batis N, Taylor G, Nankivell P, Mehanna H. Circulating Tumour Cell Biomarkers in Head and Neck Cancer: Current Progress and Future Prospects. Cancers. 2019; 11(8):1115. https://doi.org/10.3390/cancers11081115
Chicago/Turabian StylePayne, Karl, Jill Brooks, Rachel Spruce, Nikolaos Batis, Graham Taylor, Paul Nankivell, and Hisham Mehanna. 2019. "Circulating Tumour Cell Biomarkers in Head and Neck Cancer: Current Progress and Future Prospects" Cancers 11, no. 8: 1115. https://doi.org/10.3390/cancers11081115