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Open AccessCommunication

Stereotactic Body Radiotherapy as a Salvage Therapy after Incomplete Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Propensity Score Matching Study

1
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
2
Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
3
Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
*
Author to whom correspondence should be addressed.
The first three authors contributed equally to this work.
Cancers 2019, 11(8), 1116; https://doi.org/10.3390/cancers11081116
Received: 5 July 2019 / Revised: 19 July 2019 / Accepted: 23 July 2019 / Published: 5 August 2019
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Abstract

Abstract: (1) Background: To investigate the clinical outcomes between radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) for residual hepatocellular carcinoma (RHCC). (2) Methods: 139 patients were diagnosed with the RHCC after post-operative checkup, among whom 39 and 33 patients underwent RFA or SBRT as salvage treatments, respectively. We applied the propensity score matching (PSM) to adjust for imbalances in treatment assignment. Local disease progression, progression-free survival (PFS), overall survival (OS), and treatment-related side effects were the study endpoints. (3) Results: Before PSM, the SBRT group demonstrated significantly lower local disease progression rate (6/33 vs. 23/39; p = 0.002), better PFS (the 1- and 3-year PFS were 63.3% and 49.3% vs. 41.5% and 22.3%, respectively, p = 0.036), and comparable OS (the 1- and 3-year OS were 85.4% and 71.1% vs. 97.3% and 57.6%, respectively, p = 0.680). After PSM of 23 matched cases, the SBRT group demonstrated significantly lower local disease progression rate, better PFS and comparable OS. Centrally located tumor predicted the worse OS. No acute grade 3+ toxicity was observed in both groups. (4) Conclusion: SBRT might be the preferred treatment for RHCC, especially for patients with larger tumors or tumors abutting major vessels, rather than repeated RFA. View Full-Text
Keywords: stereotactic body radiotherapy; radiofrequency ablation; hepatocellular carcinoma; propensity score matching stereotactic body radiotherapy; radiofrequency ablation; hepatocellular carcinoma; propensity score matching
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Pan, Y.-X.; Xi, M.; Fu, Y.-Z.; Hu, D.-D.; Wang, J.-C.; Liu, S.-L.; Chen, J.-B.; Xu, L.; Zhou, Z.-G.; Liu, M.-Z.; Chen, M.-S.; Zhao, L.; Zhang, Y.-J. Stereotactic Body Radiotherapy as a Salvage Therapy after Incomplete Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Propensity Score Matching Study. Cancers 2019, 11, 1116.

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