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by
  • Ivana Jovčevska1,*,†,
  • Alja Zottel1 and
  • Neja Šamec1
  • et al.

Reviewer 1: Anonymous Reviewer 2: Anonymous Reviewer 3: Anonymous

Round 1

Reviewer 1 Report

The manuscript has improved a lot. However, there are still a few criticisms which should be addressed:

Fig. 3A: Pictures of non-malignant brains do not contain a proper counterstaining of nuclei by hemataoxilin. Scale bar to inform about the magnification is missing. All pictures should have the same magnification.

Firg. 3B: This graphical presentation does not fit. It should be a bar plot and every bar should represent a staining score for the different WHO grades.

Whenever LGG TCGA data are used, please be precise that these are not low-grade (WHO°II) but lower-grade (WHO°II +III) tumors.

Table 2: A macroscopic evaluation of tumor resection is not possible. This can onlybe done by intra- or early postoperative MRI. If this has not been done please remove this part of the table.

Author Response

Please see attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

A good finding with nicely written manuscript

Author Response

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Author Response File: Author Response.pdf

Reviewer 3 Report

Authors answered comments.

Author Response

Please see attachment.

Author Response File: Author Response.pdf