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Peer-Review Record

High FREM2 Gene and Protein Expression Are Associated with Favorable Prognosis of IDH-WT Glioblastomas

Cancers 2019, 11(8), 1060; https://doi.org/10.3390/cancers11081060
by Ivana Jovčevska 1,*,†, Alja Zottel 1, Neja Šamec 1, Jernej Mlakar 2, Maxim Sorokin 3,4,5, Daniil Nikitin 3,5, Anton A. Buzdin 3,5,6 and Radovan Komel 1,†
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Cancers 2019, 11(8), 1060; https://doi.org/10.3390/cancers11081060
Submission received: 10 July 2019 / Revised: 24 July 2019 / Accepted: 25 July 2019 / Published: 27 July 2019

Round 1

Reviewer 1 Report

The manuscript has improved a lot. However, there are still a few criticisms which should be addressed:

Fig. 3A: Pictures of non-malignant brains do not contain a proper counterstaining of nuclei by hemataoxilin. Scale bar to inform about the magnification is missing. All pictures should have the same magnification.

Firg. 3B: This graphical presentation does not fit. It should be a bar plot and every bar should represent a staining score for the different WHO grades.

Whenever LGG TCGA data are used, please be precise that these are not low-grade (WHO°II) but lower-grade (WHO°II +III) tumors.

Table 2: A macroscopic evaluation of tumor resection is not possible. This can onlybe done by intra- or early postoperative MRI. If this has not been done please remove this part of the table.

Author Response

Please see attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

A good finding with nicely written manuscript

Author Response

Please see attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

Authors answered comments.

Author Response

Please see attachment.

Author Response File: Author Response.pdf

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