Next Article in Journal
Breath Analysis: A Systematic Review of Volatile Organic Compounds (VOCs) in Diagnostic and Therapeutic Management of Pleural Mesothelioma
Next Article in Special Issue
Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor
Previous Article in Journal
Optimizing Neuro-Oncology Imaging: A Review of Deep Learning Approaches for Glioma Imaging
Previous Article in Special Issue
Improving the Brain Delivery of Chemotherapeutic Drugs in Childhood Brain Tumors
Review

Resistance to Systemic Agents in Renal Cell Carcinoma Predict and Overcome Genomic Strategies Adopted by Tumor

1
Division of Oncology, S.Orsola-Malpighi Hospital, 40138 Bologna, Italy
2
Oncology Unit, Macerata Hospital, 62100 Macerata, Italy
3
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, I−60126 Ancona, Italy
4
Department of Pathology and Surgery, Faculty of Medicine, University of Córdoba, 14071 Cordoba, Spain
5
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
*
Authors to whom correspondence should be addressed.
These authors share equal contribution.
These authors share equal senior authorship.
Cancers 2019, 11(6), 830; https://doi.org/10.3390/cancers11060830
Received: 29 April 2019 / Revised: 25 May 2019 / Accepted: 11 June 2019 / Published: 14 June 2019
(This article belongs to the Collection Drug Resistance and Novel Therapies in Cancers)
The development of new systemic agents has led us into a “golden era” of management of metastatic renal cell carcinoma (RCC). Certainly, the approval of immune-checkpoint inhibitors and the combination of these with targeted compounds has irreversibly changed clinical scenarios. A deeper knowledge of the molecular mechanisms that correlate with tumor development and progression has made this revolution possible. In this amazing era, novel challenges are awaiting us in the clinical management of metastatic RCC. Of these, the development of reliable criteria which are able to predict tumor response to treatment or primary and acquired resistance to systemic treatments still remain an unmet clinical need. Thanks to the availability of data provided by studies evaluating genomic assessments of the disease, this goal may no longer be out of reach. In this review, we summarize current knowledge about genomic alterations related to primary and secondary resistance to target therapy and immune-checkpoint inhibitors in RCC. View Full-Text
Keywords: renal cell carcinoma; VEGFR; VEGF; mTOR; PD-1/PD-L1; immune-checkpoint inhibitors; target therapy; primary resistance; acquired resistance; predictive markers renal cell carcinoma; VEGFR; VEGF; mTOR; PD-1/PD-L1; immune-checkpoint inhibitors; target therapy; primary resistance; acquired resistance; predictive markers
Show Figures

Figure 1

MDPI and ACS Style

Mollica, V.; Di Nunno, V.; Gatto, L.; Santoni, M.; Scarpelli, M.; Cimadamore, A.; Lopez-Beltran, A.; Cheng, L.; Battelli, N.; Montironi, R.; Massari, F. Resistance to Systemic Agents in Renal Cell Carcinoma Predict and Overcome Genomic Strategies Adopted by Tumor. Cancers 2019, 11, 830. https://doi.org/10.3390/cancers11060830

AMA Style

Mollica V, Di Nunno V, Gatto L, Santoni M, Scarpelli M, Cimadamore A, Lopez-Beltran A, Cheng L, Battelli N, Montironi R, Massari F. Resistance to Systemic Agents in Renal Cell Carcinoma Predict and Overcome Genomic Strategies Adopted by Tumor. Cancers. 2019; 11(6):830. https://doi.org/10.3390/cancers11060830

Chicago/Turabian Style

Mollica, Veronica, Vincenzo Di Nunno, Lidia Gatto, Matteo Santoni, Marina Scarpelli, Alessia Cimadamore, Antonio Lopez-Beltran, Liang Cheng, Nicola Battelli, Rodolfo Montironi, and Francesco Massari. 2019. "Resistance to Systemic Agents in Renal Cell Carcinoma Predict and Overcome Genomic Strategies Adopted by Tumor" Cancers 11, no. 6: 830. https://doi.org/10.3390/cancers11060830

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop