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Open AccessArticle

On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas

1
Braunschweig Integrated Centre of Systems Biology and Helmholtz Center for Infectious Research, 38106 Braunschweig, Germany
2
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, Germany
3
Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678 Nicosia, Cyprus
4
Centre for Individualized Infection Medicine, 30625 Hannover, Germany
5
Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, 38106 Braunschweig, Germany
*
Authors to whom correspondence should be addressed.
Cancers 2019, 11(5), 716; https://doi.org/10.3390/cancers11050716
Received: 11 March 2019 / Revised: 7 May 2019 / Accepted: 17 May 2019 / Published: 24 May 2019
(This article belongs to the Special Issue Targeting Solid Tumors)
Tumor microenvironment is a critical player in glioma progression, and novel therapies for its targeting have been recently proposed. In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, decreasing solid stresses and improving blood perfusion. However, these microenvironmental changes trigger chemo–mechanically induced cellular phenotypic transitions whose impact on therapy outcomes is not completely understood. In this work we analyze the effects of mechanical compression on migration and proliferation of glioma cells. We derive a mathematical model of glioma progression focusing on cellular phenotypic plasticity. Our results reveal a trade-off between tumor infiltration and cellular content as a consequence of stress-alleviation approaches. We discuss how these novel findings increase the current understanding of glioma/microenvironment interactions and can contribute to new strategies for improved therapeutic outcomes. View Full-Text
Keywords: glioma; solid stress; phenotypic transitions; stress-alleviation therapy glioma; solid stress; phenotypic transitions; stress-alleviation therapy
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MDPI and ACS Style

Mascheroni, P.; López Alfonso, J.C.; Kalli, M.; Stylianopoulos, T.; Meyer-Hermann, M.; Hatzikirou, H. On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas. Cancers 2019, 11, 716. https://doi.org/10.3390/cancers11050716

AMA Style

Mascheroni P, López Alfonso JC, Kalli M, Stylianopoulos T, Meyer-Hermann M, Hatzikirou H. On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas. Cancers. 2019; 11(5):716. https://doi.org/10.3390/cancers11050716

Chicago/Turabian Style

Mascheroni, Pietro; López Alfonso, Juan C.; Kalli, Maria; Stylianopoulos, Triantafyllos; Meyer-Hermann, Michael; Hatzikirou, Haralampos. 2019. "On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas" Cancers 11, no. 5: 716. https://doi.org/10.3390/cancers11050716

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