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Open AccessArticle

Delineation of Tumor Migration Paths by Using a Bayesian Biogeographic Approach

by Antonia Chroni 1,2,*, Tracy Vu 1,2, Sayaka Miura 1,2 and Sudhir Kumar 1,2,3
Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA
Department of Biology, Temple University, Philadelphia, PA 19122, USA
Center for Excellence in Genome Medicine and Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Author to whom correspondence should be addressed.
Cancers 2019, 11(12), 1880;
Received: 17 October 2019 / Revised: 20 November 2019 / Accepted: 26 November 2019 / Published: 27 November 2019
(This article belongs to the Collection Application of Bioinformatics in Cancers)
Understanding tumor progression and metastatic potential are important in cancer biology. Metastasis is the migration and colonization of clones in secondary tissues. Here, we posit that clone migration events between tumors resemble the dispersal of individuals between distinct geographic regions. This similarity makes Bayesian biogeographic analysis suitable for inferring cancer cell migration paths. We evaluated the accuracy of a Bayesian biogeography method (BBM) in inferring metastatic patterns and compared it with the accuracy of a parsimony-based approach (metastatic and clonal history integrative analysis, MACHINA) that has been specifically developed to infer clone migration patterns among tumors. We used computer-simulated datasets in which simple to complex migration patterns were modeled. BBM and MACHINA were effective in reliably reconstructing simple migration patterns from primary tumors to metastases. However, both of them exhibited a limited ability to accurately infer complex migration paths that involve the migration of clones from one metastatic tumor to another and from metastasis to the primary tumor. Therefore, advanced computational methods are still needed for the biologically realistic tracing of migration paths and to assess the relative preponderance of different types of seeding and reseeding events during cancer progression in patients. View Full-Text
Keywords: biogeography; cancer; dispersal; metastasis; migration paths; tumor biogeography; cancer; dispersal; metastasis; migration paths; tumor
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Chroni, A.; Vu, T.; Miura, S.; Kumar, S. Delineation of Tumor Migration Paths by Using a Bayesian Biogeographic Approach. Cancers 2019, 11, 1880.

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