Next Article in Journal
Epstein–Barr Virus Gene BARF1 Expression is Regulated by the Epithelial Differentiation Factor ΔNp63α in Undifferentiated Nasopharyngeal Carcinoma
Next Article in Special Issue
Should We Keep Walking along the Trail for Pancreatic Cancer Treatment? Revisiting TNF-Related Apoptosis-Inducing Ligand for Anticancer Therapy
Previous Article in Journal
Correction: Alessia Stornetta et al. Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity. Cancers 2018, 10, 20
Previous Article in Special Issue
Advanced EUS Guided Tissue Acquisition Methods for Pancreatic Cancer
Review

Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Cancers 2018, 10(3), 75; https://doi.org/10.3390/cancers10030075
Received: 24 February 2018 / Revised: 10 March 2018 / Accepted: 14 March 2018 / Published: 16 March 2018
(This article belongs to the Special Issue Latest Development in Pancreatic Cancer)
Pancreatic cancer is a devastating disease with poor survival outcomes. Recent studies have shown that the addition of radiotherapy to chemotherapy in the setting of locally advanced pancreatic cancer did not improve overall survival outcome. These studies commonly utilize conventional radiotherapy treatment fractionation and technique (typically 3-D conformal radiotherapy or intensity modulated radiotherapy). Although no clear benefit in overall survival was demonstrated in those studies, those who received radiotherapy did have a clear benefit in terms of local control. Therefore, there is increasing interest in exploring different techniques and/or modality of radiotherapy and dose/fractionation. Stereotactic radiotherapy, which employs a hypofractionated regimen, has the potential advantage of delivering a high dose of radiation to the tumor in a short period of time (typically over 5 days) with minimal dose to the surrounding normal structures. Particle therapy such as proton and carbon ion therapy are being explored as potential radiation modality that could cause greater biological damage to the tumor compared to photon treatment, with rapid dose falloff resulting in minimal to no dose to adjacent structures. This review will discuss the current literature and emerging roles of stereotactic radiotherapy and particle therapy in pancreatic cancer. View Full-Text
Keywords: radiotherapy; stereotactic; proton; carbon; pancreatic cancer radiotherapy; stereotactic; proton; carbon; pancreatic cancer
Show Figures

Figure 1

MDPI and ACS Style

Ng, S.P.; Herman, J.M. Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer. Cancers 2018, 10, 75. https://doi.org/10.3390/cancers10030075

AMA Style

Ng SP, Herman JM. Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer. Cancers. 2018; 10(3):75. https://doi.org/10.3390/cancers10030075

Chicago/Turabian Style

Ng, Sweet P., and Joseph M. Herman 2018. "Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer" Cancers 10, no. 3: 75. https://doi.org/10.3390/cancers10030075

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop