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Micromachines 2017, 8(3), 80;

Transfer Function of Macro-Micro Manipulation on a PDMS Microfluidic Chip

Department of Mechanical Engineering, Osaka University, Suita 565-0871, Japan
Author to whom correspondence should be addressed.
Academic Editor: Kwang W. Oh
Received: 19 January 2017 / Revised: 20 February 2017 / Accepted: 1 March 2017 / Published: 4 March 2017
(This article belongs to the Special Issue Biomedical Microfluidic Devices)
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To achieve fast and accurate cell manipulation in a microfluidic channel, it is essential to know the true nature of its input-output relationship. This paper aims to reveal the transfer function of such a micro manipulation controlled by a macro actuator. Both a theoretical model and experimental results for the manipulation are presented. A second-order transfer function is derived based on the proposed model, where the polydimethylsiloxane (PDMS) deformation plays an important role in the manipulation. Experiments are conducted with input frequencies up to 300 Hz. An interesting observation from the experimental results is that the frequency responses of the transfer function behave just like a first-order integration operator in the system. The role of PDMS deformation for the transfer function is discussed based on the experimentally-determined parameters and the proposed model. View Full-Text
Keywords: cell manipulation; transfer function; microfluidic channel; macro actuator cell manipulation; transfer function; microfluidic channel; macro actuator

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Mizoue, K.; Teramura, K.; Tsai, C.-H.D.; Kaneko, M. Transfer Function of Macro-Micro Manipulation on a PDMS Microfluidic Chip. Micromachines 2017, 8, 80.

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