Next Article in Journal
Theoretical and Experimental Investigations of Tool Tip Vibration in Single Point Diamond Turning of Titanium Alloys
Previous Article in Journal
Design Optimization of Double-Gate Isosceles Trapezoid Tunnel Field-Effect Transistor (DGIT-TFET)
Article

Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery

1
Weinberg Medical Physics, Inc., North Bethesda, MD 20852, USA
2
Multi-Scale Robotics and Automation Lab, School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA
3
Russel H. Morgan Department of Radiology, Division of Magnetic Resonance Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
4
Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
5
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
6
Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
7
Department of Chemical & Biomolecular Engineering, The Johns Hopkins School of Engineering, Baltimore, MD 21218, USA
8
Department of Physics, Elon University, Elon, NC 27244, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Micromachines 2019, 10(4), 230; https://doi.org/10.3390/mi10040230
Received: 16 February 2019 / Revised: 23 March 2019 / Accepted: 27 March 2019 / Published: 31 March 2019
(This article belongs to the Section D:Materials and Processing)
Soft, untethered microrobots composed of biocompatible materials for completing micromanipulation and drug delivery tasks in lab-on-a-chip and medical scenarios are currently being developed. Alginate holds significant potential in medical microrobotics due to its biocompatibility, biodegradability, and drug encapsulation capabilities. Here, we describe the synthesis of MANiACs—Magnetically Aligned Nanorods in Alginate Capsules—for use as untethered microrobotic surface tumblers, demonstrating magnetically guided lateral tumbling via rotating magnetic fields. MANiAC translation is demonstrated on tissue surfaces as well as inclined slopes. These alginate microrobots are capable of manipulating objects over millimeter-scale distances. Finally, we demonstrate payload release capabilities of MANiACs during translational tumbling motion. View Full-Text
Keywords: alginate capsules; magnetic nanorods; magnetic microrobots; tumbling robots; surface walkers; rotating magnetic fields; micromanipulation alginate capsules; magnetic nanorods; magnetic microrobots; tumbling robots; surface walkers; rotating magnetic fields; micromanipulation
Show Figures

Graphical abstract

MDPI and ACS Style

Mair, L.O.; Chowdhury, S.; Paredes-Juarez, G.A.; Guix, M.; Bi, C.; Johnson, B.; English, B.W.; Jafari, S.; Baker-McKee, J.; Watson-Daniels, J.; Hale, O.; Stepanov, P.; Sun, D.; Baker, Z.; Ropp, C.; Raval, S.B.; Arifin, D.R.; Bulte, J.W.M.; Weinberg, I.N.; Evans, B.A.; Cappelleri, D.J. Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery. Micromachines 2019, 10, 230. https://doi.org/10.3390/mi10040230

AMA Style

Mair LO, Chowdhury S, Paredes-Juarez GA, Guix M, Bi C, Johnson B, English BW, Jafari S, Baker-McKee J, Watson-Daniels J, Hale O, Stepanov P, Sun D, Baker Z, Ropp C, Raval SB, Arifin DR, Bulte JWM, Weinberg IN, Evans BA, Cappelleri DJ. Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery. Micromachines. 2019; 10(4):230. https://doi.org/10.3390/mi10040230

Chicago/Turabian Style

Mair, Lamar O., Sagar Chowdhury, Genaro A. Paredes-Juarez, Maria Guix, Chenghao Bi, Benjamin Johnson, Bradley W. English, Sahar Jafari, James Baker-McKee, Jamelle Watson-Daniels, Olivia Hale, Pavel Stepanov, Danica Sun, Zachary Baker, Chad Ropp, Shailesh B. Raval, Dian R. Arifin, Jeff W.M. Bulte, Irving N. Weinberg, Benjamin A. Evans, and David J. Cappelleri 2019. "Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery" Micromachines 10, no. 4: 230. https://doi.org/10.3390/mi10040230

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop