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Micromachines 2019, 10(2), 84; https://doi.org/10.3390/mi10020084

Three-Dimensional Au/Holey-Graphene as Efficient Electrochemical Interface for Simultaneous Determination of Ascorbic Acid, Dopamine and Uric Acid

1
School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471003, China
2
Medical College, Henan University of Science and Technology, Luoyang 471003, China
3
Food Science College, Northeast Agricultural University, Harbin 150030, China
*
Author to whom correspondence should be addressed.
Received: 15 December 2018 / Revised: 18 January 2019 / Accepted: 20 January 2019 / Published: 24 January 2019
(This article belongs to the Special Issue Conductive Nanomaterial-Based Chem/Bio Sensors)
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Abstract

The quantification of ascorbic acid (AA), dopamine (DA), and uric acid (UA) has been an important area of research, as these molecules’ determination directly corresponds to the diagnosis and control of diseases of nerve and brain physiology. In our research, graphene oxide (GO) with nano pores deposited with gold nanoparticles were self-assembled to form three-dimensional (3D) Au/holey-graphene oxide (Au/HGO) composite structures. The as-prepared 3DAu/HGO composite structures were characterized for their structures by X-ray diffraction, Raman spectrum, scanning electron microscopy, and transmission electron microscopy coupled with cyclic voltammograms. Finally, the proposed 3DAu/HGO displayed high sensitivity, excellent electron transport properties, and selectivity for the simultaneous electrochemical determination of AA, DA and UA with linear response ranges of 1.0–500 μM, 0.01–50 μM and 0.05–50 μM respectively. This finding paves the way for graphene applications as a biosensor for detecting three analytes in human serum. View Full-Text
Keywords: graphene; gold; electrochemical; ascorbic acid; dopamine; uric acid graphene; gold; electrochemical; ascorbic acid; dopamine; uric acid
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Jing, A.; Liang, G.; Yuan, Y.; Feng, W. Three-Dimensional Au/Holey-Graphene as Efficient Electrochemical Interface for Simultaneous Determination of Ascorbic Acid, Dopamine and Uric Acid. Micromachines 2019, 10, 84.

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