Micromachines 2019, 10(2), 125; https://doi.org/10.3390/mi10020125
Coaxial Electrohydrodynamic Atomization for the Production of Drug-Loaded Micro/Nanoparticles
School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China
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Received: 18 January 2019 / Revised: 10 February 2019 / Accepted: 12 February 2019 / Published: 14 February 2019
Abstract
Coaxial electrohydrodynamic atomization (CEHDA) presents a promising technology for preparing drug-loaded micro/nanoparticles with core-shell structures. Recently, CEHDA has attracted tremendous attention based on its specific advantages, including precise control over particle size and size distribution, reduced initial burst release and mild preparation conditions. Moreover, with different needles, CEHDA can produce a variety of drug-loaded micro/nanoparticles for drug delivery systems. In this review, we summarize recent advances in using double-layer structure, multilayer structure and multicomponent encapsulation strategies for developing micro/nanoparticles. The merits of applying multiplexed electrospray sources for high-throughput production are also highlighted. View Full-Text
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chen, C.; Liu, W.; Jiang, P.; Hong, T. Coaxial Electrohydrodynamic Atomization for the Production of Drug-Loaded Micro/Nanoparticles. Micromachines 2019, 10, 125.
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