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Correction published on 23 March 2018, see Toxins 2018, 10(4), 132.

Open AccessFeature PaperReview
Toxins 2017, 9(10), 333; https://doi.org/10.3390/toxins9100333

Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing

Molecular and Cell Biology, Department of Biosciences and Center of Human and Molecular Biology (ZHMB), Saarland University, D-66123 Saarbrücken, Germany
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Author to whom correspondence should be addressed.
Academic Editor: Holger Barth
Received: 29 September 2017 / Revised: 12 October 2017 / Accepted: 17 October 2017 / Published: 20 October 2017
(This article belongs to the Special Issue Yeast Killer Toxins)
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Abstract

The initial discovery of killer toxin-secreting brewery strains of Saccharomyces cerevisiae (S. cerevisiae) in the mid-sixties of the last century marked the beginning of intensive research in the yeast virology field. So far, four different S. cerevisiae killer toxins (K28, K1, K2, and Klus), encoded by cytoplasmic inherited double-stranded RNA viruses (dsRNA) of the Totiviridae family, have been identified. Among these, K28 represents the unique example of a yeast viral killer toxin that enters a sensitive cell by receptor-mediated endocytosis to reach its intracellular target(s). This review summarizes and discusses the most recent advances and current knowledge on yeast killer toxin K28, with special emphasis on its endocytosis and intracellular trafficking, pointing towards future directions and open questions in this still timely and fascinating field of killer yeast research. View Full-Text
Keywords: K28; killer toxin; S. cerevisiae; A/B toxin; cell wall receptor; H/KDEL receptor; retrograde protein transport; retrotranslocation; cell cycle arrest; toxin immunity K28; killer toxin; S. cerevisiae; A/B toxin; cell wall receptor; H/KDEL receptor; retrograde protein transport; retrotranslocation; cell cycle arrest; toxin immunity
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Becker, B.; Schmitt, M.J. Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing. Toxins 2017, 9, 333.

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