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Toxins 2017, 9(10), 334; https://doi.org/10.3390/toxins9100334

Chronic Exposure to the Fusarium Mycotoxin Deoxynivalenol: Impact on Performance, Immune Organ, and Intestinal Integrity of Slow-Growing Chickens

Department of Animal Science and Technology, National Taiwan University, Taipei 10673, Taiwan
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Academic Editor: Sven Dänicke
Received: 31 August 2017 / Revised: 13 October 2017 / Accepted: 15 October 2017 / Published: 20 October 2017
(This article belongs to the Collection Fusarium Toxins – Relevance for Human and Animal Health)
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Abstract

This study investigates the long-term effects of deoxynivalenol (DON) consumption on avian growth performance, on the proliferation, apoptosis, and DNA damage of spleen cells, and on intestinal integrity. Two hundred and eight 5-day-old black-feathered Taiwan country chickens were fed diets containing 0, 2, 5, and 10 mg/kg of DON for 16 weeks. Body weight gain of male birds in the 2 mg/kg group was significantly lower than that in the 5 mg/kg group. At the end of trial, feeding DON-contaminated diets of 5 mg/kg resulted in heavier spleens. Moreover, the increase in DON induced cellular proliferation, apoptosis, and DNA damage signals in the spleen, the exception being female birds fed 10 mg/kg of DON showing reduced proliferation. Expression of claudin-5 was increased in jejunum of female birds fed 2 and 5 mg/kg of DON, whereas decreased expression levels were found in male birds. In conclusion, our results verified that DON may cause a disturbance to the immune system and alter the intestinal barrier in Taiwan country chickens, and may also lead to discrepancies in growth performances in a dose- and sex-dependent manner. View Full-Text
Keywords: deoxynivalenol; chicken; spleen; intestine; tight junction; immunohistochemistry; long-term effects deoxynivalenol; chicken; spleen; intestine; tight junction; immunohistochemistry; long-term effects
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Chen, S.S.; Li, Y.-H.; Lin, M.-F. Chronic Exposure to the Fusarium Mycotoxin Deoxynivalenol: Impact on Performance, Immune Organ, and Intestinal Integrity of Slow-Growing Chickens. Toxins 2017, 9, 334.

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