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Biosynthetic Pathways of Ergot Alkaloids
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Diversification of Ergot Alkaloids in Natural and Modified Fungi

Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV 26506, USA
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Academic Editor: Christopher L. Schardl
Toxins 2015, 7(1), 201-218; https://doi.org/10.3390/toxins7010201
Received: 21 November 2014 / Accepted: 14 January 2015 / Published: 20 January 2015
(This article belongs to the Special Issue Ergot Alkaloids: Chemistry, Biology and Toxicology)
Several fungi in two different families––the Clavicipitaceae and the Trichocomaceae––produce different profiles of ergot alkaloids, many of which are important in agriculture and medicine. All ergot alkaloid producers share early steps before their pathways diverge to produce different end products. EasA, an oxidoreductase of the old yellow enzyme class, has alternate activities in different fungi resulting in branching of the pathway. Enzymes beyond the branch point differ among lineages. In the Clavicipitaceae, diversity is generated by the presence or absence and activities of lysergyl peptide synthetases, which interact to make lysergic acid amides and ergopeptines. The range of ergopeptines in a fungus may be controlled by the presence of multiple peptide synthetases as well as by the specificity of individual peptide synthetase domains. In the Trichocomaceae, diversity is generated by the presence or absence of the prenyl transferase encoded by easL (also called fgaPT1). Moreover, relaxed specificity of EasL appears to contribute to ergot alkaloid diversification. The profile of ergot alkaloids observed within a fungus also is affected by a delayed flux of intermediates through the pathway, which results in an accumulation of intermediates or early pathway byproducts to concentrations comparable to that of the pathway end product. View Full-Text
Keywords: ergot alkaloids; Claviceps; Epichloë, Neosartorya fumigata, old yellow enzyme; peptide synthetase; prenyl transferase ergot alkaloids; Claviceps; Epichloë, Neosartorya fumigata, old yellow enzyme; peptide synthetase; prenyl transferase
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Robinson, S.L.; Panaccione, D.G. Diversification of Ergot Alkaloids in Natural and Modified Fungi. Toxins 2015, 7, 201-218.

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