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Postprandial Effects of Breakfast Glycemic Index on Vascular Function among Young Healthy Adults: A Crossover Clinical Trial

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Primary Care Research Unit, The Alamedilla Health Center, Castilla and Leon Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), 37003 Salamanca, Spain
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Primary Care Research Unit, The Alamedilla Health Center, Biomedical Research Institute of Salamanca (IBSAL), Department of Statistics, University of Salamanca, 37003 Salamanca, Spain
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Primary Care Research Unit, The Alamedilla Health Center, Biomedical Research Institute of Salamanca (IBSAL), School of Labor Relations of Zamora, University of Salamanca Affiliated Center, 37003 Salamanca, Spain
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Primary Care Research Unit, The Alamedilla Health Center, Castilla and Leon Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Department of Medicine, University of Salamanca, 37003 Salamanca, Spain
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Primary Care Research Unit, The Alamedilla Health Center, Castilla and Leon Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Department of Nursing and Physiotherapy, University of Salamanca, 37003 Salamanca, Spain
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Primary Care Research Unit, The Alamedilla Health Center, Castilla and Leon Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Department of Biomedical and Diagnostic Sciences, University of Salamanca, 37003 Salamanca, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2017, 9(7), 712; https://doi.org/10.3390/nu9070712
Received: 25 May 2017 / Revised: 2 July 2017 / Accepted: 5 July 2017 / Published: 7 July 2017
This study aimed to evaluate the postprandial effects of high and low glycemic index (GI) breakfasts on vascular function. It was a crossover trial that included 40 young healthy adults (50% women), aged 20–40 years, who were recruited at primary care settings. They consumed three experimental breakfasts in randomized order, each one separated by a 1-week washout period: (1) control conditions (only water); (2) low GI (LGI) breakfast (29.4 GI and 1489 KJ energy); and (3) high GI (HGI) breakfast (64.0 GI and 1318 KJ energy). Blood samples were collected at 60 and 120 min after each breakfast to determine glucose and insulin levels. Vascular parameters were measured at 15 min intervals. Augmentation index (AIx) was studied as a primary outcome. Secondary outcomes comprised glucose, insulin, heart rate (HR) and pulse pressures (PPs). We found a trend toward increased AIx, HR and PPs for the HGI versus the LGI breakfast. A significant interaction between the type of breakfast consumed and all measured parameters was identified (p < 0.05) except for central PP. Stratifying data by sex, this interaction remained significant for AIx and augmentation pressure only in males (p < 0.05). In conclusion, breakfast GI could affect postprandial vascular responses in young healthy adults. View Full-Text
Keywords: breakfast; glycemic index; postprandial period; hemodynamics; vascular stiffness; blood glucose breakfast; glycemic index; postprandial period; hemodynamics; vascular stiffness; blood glucose
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Sanchez-Aguadero, N.; Patino-Alonso, M.C.; Mora-Simon, S.; Gomez-Marcos, M.A.; Alonso-Dominguez, R.; Sanchez-Salgado, B.; Recio-Rodriguez, J.I.; Garcia-Ortiz, L. Postprandial Effects of Breakfast Glycemic Index on Vascular Function among Young Healthy Adults: A Crossover Clinical Trial. Nutrients 2017, 9, 712.

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