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Stirring the Pot: Can Dietary Modification Alleviate the Burden of CKD?

by Matthew Snelson 1,*,†, Rachel E. Clarke 1,2,† and Melinda T. Coughlan 1,3,*
1
Glycation, Nutrition and Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne 3004, Australia
2
Department of Physiology, Monash University, Clayton 3800, Australia
3
Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne 3004, Australia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2017, 9(3), 265; https://doi.org/10.3390/nu9030265
Received: 23 January 2017 / Revised: 27 February 2017 / Accepted: 6 March 2017 / Published: 11 March 2017
(This article belongs to the Special Issue Nutrition and Chronic Kidney Disease)
Diet is one of the largest modifiable risk factors for chronic kidney disease (CKD)-related death and disability. CKD is largely a progressive disease; however, it is increasingly appreciated that hallmarks of chronic kidney disease such as albuminuria can regress over time. The factors driving albuminuria resolution remain elusive. Since albuminuria is a strong risk factor for GFR loss, modifiable lifestyle factors that lead to an improvement in albuminuria would likely reduce the burden of CKD in high-risk individuals, such as patients with diabetes. Dietary therapy such as protein and sodium restriction has historically been used in the management of CKD. Evidence is emerging to indicate that other nutrients may influence kidney health, either through metabolic or haemodynamic pathways or via the modification of gut homeostasis. This review focuses on the role of diet in the pathogenesis and progression of CKD and discusses the latest findings related to the mechanisms of diet-induced kidney disease. It is possible that optimizing diet quality or restricting dietary intake could be harnessed as an adjunct therapy for CKD prevention or progression in susceptible individuals, thereby reducing the burden of CKD. View Full-Text
Keywords: advanced glycation end products; albuminuria; diet; chronic kidney disease; diabetes; cardiovascular disease; inflammation advanced glycation end products; albuminuria; diet; chronic kidney disease; diabetes; cardiovascular disease; inflammation
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Snelson, M.; Clarke, R.E.; Coughlan, M.T. Stirring the Pot: Can Dietary Modification Alleviate the Burden of CKD? Nutrients 2017, 9, 265.

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