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Analgesic Effect of Indian Gooseberry (Emblica officinalis Fruit) Extracts on Postoperative and Neuropathic Pain in Rats

by Dong Wook Lim 1,†, Jae Goo Kim 1,† and Yun Tai Kim 1,2,*
1
Research Group of Innovative Special Food, Korea Food Research Institute, 62, Anyangpangyo-ro, Bundang-gu, Seongnam 13539, Korea
2
Department of Food Biotechnology, Korea University of Science & Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(12), 760; https://doi.org/10.3390/nu8120760
Received: 29 July 2016 / Revised: 27 October 2016 / Accepted: 18 November 2016 / Published: 26 November 2016
Indian gooseberry (Emblica officinalis fruit), also known as “Amla” is one of the oldest edible fruits known in India. It has also traditionally been used to treat inflammation, and as an analgesic to treat wounds. However, experimental evidence for the analgesic effects of E. officinalis has been lacking. The present study investigated whether E. officinalis extracts exhibit analgesic effects in the plantar incision (PI) and spared nerve injury (SNI) pain-model rats. We evaluated the mechanical withdrawal threshold (MWT) using von Frey filaments, and pain-related behavior was determined after surgery based on ultrasonic vocalization (USV). The group treated with E. officinalis extracts at 300 mg/kg had significantly increased MWT values at 6 h and 24 h after the PI, and had a significantly reduced number of 22–27-kHz USVs at 6 h and 24 h after PI. Moreover, after 15 days of continuous treatment with E. officinalis extracts, the treated group showed significantly alleviated SNI-induced hypersensitivity and reduced pro-inflammatory cytokine levels. Thus, E. officinalis extracts have potential analgesic effects in both postoperative and neuropathic pain models in vivo. View Full-Text
Keywords: analgesic effects; anti-inflammation; Emblica officinalis; Indian gooseberry; pain; plantar incision; spared nerve injury analgesic effects; anti-inflammation; Emblica officinalis; Indian gooseberry; pain; plantar incision; spared nerve injury
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Lim, D.W.; Kim, J.G.; Kim, Y.T. Analgesic Effect of Indian Gooseberry (Emblica officinalis Fruit) Extracts on Postoperative and Neuropathic Pain in Rats. Nutrients 2016, 8, 760.

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