Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults
AbstractWe aimed to investigate associations of the dietary inflammatory index (DII) with glucose-insulin homeostasis markers, and the risk of glucose intolerance. This cross-sectional study included 2975 adults from the Tehran Lipid and Glucose Study. Fasting plasma glucose (FPG), 2-h post-load glucose (2h-PG), and fasting serum insulin were measured. Homeostatic model assessment of insulin resistance index (HOMA-IR) and β-cell function (HOMA-B), and the quantitative insulin sensitivity check index (QUICKI) were calculated. Glucose tolerance abnormalities included impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2DM). DII scores were positively associated with 2h-PG (β = 0.04; p = 0.05). There was no significant linear trend across quartiles of DII for adjusted means of glucose-insulin homeostasis markers. Participants in the highest quartile of DII score tended to have higher FPG compared to those in the second quartile of DII score (5.46 vs. 5.38 mmol/L, p = 0.07) and higher fasting insulin and HOMA-IR compared to those in the lowest quartile (8.52 vs. 8.12 µU/mL for fasting insulin, p = 0.07; 2.06 vs. 1.96 for HOMA-IR, p = 0.08). No significant associations were observed between DII and risk of IFG, IGT, T2DM, and insulin resistance. Among glucose-insulin homeostasis markers, DII had a positive weak association only with 2h-PG. View Full-Text
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Moslehi, N.; Ehsani, B.; Mirmiran, P.; Shivappa, N.; Tohidi, M.; Hébert, J.R.; Azizi, F. Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults. Nutrients 2016, 8, 735.
Moslehi N, Ehsani B, Mirmiran P, Shivappa N, Tohidi M, Hébert JR, Azizi F. Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults. Nutrients. 2016; 8(11):735.Chicago/Turabian Style
Moslehi, Nazanin; Ehsani, Behnaz; Mirmiran, Parvin; Shivappa, Nitin; Tohidi, Maryam; Hébert, James R.; Azizi, Fereidoun. 2016. "Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults." Nutrients 8, no. 11: 735.
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